… At present, the specific function of each receptor is still under debate; here, we propose a …
relevant TNF receptor and that the binding of TNF to TNF-R2 is not sufficient to initiate TNF re…

… mechanisms utilized by the TNF receptor superfamily. There are now twelve known
members of this family, yet unambiguous evidence for direct receptor coupling with intracellular …

… TNF-… receptor interacting protein, and TNF receptor-associated factor 2 (TRAF2). TRAF2
has previously been demonstrated to activate both transcription factor nuclear factor κB (NFκB) …

… This article will review the structure/function relationships of the TNFα and the TNF receptor
superfamily. It will also discuss insights as to how structural features play a role in the …

… Activated TNF receptors mediate the … of TNF signalling, the pathways employed with their
cellular consequences, and focuses on the specific role played by each of the two TNF receptor …

… Engagement of TNF receptor 1 by TNFα activates the transcription factor NF-κB but can also
… ubiquitylation but switches TNFα signaling from NF-κB activation to apoptosis. We suggest …

… with the cytoplasmic domain of CD40, another member of the TNF receptor superfamily (12).
Because CD40 can alsosignal NF-KBactivation (13), we investigated the potential role of …

… structural and functional receptor heterogeneity, where either receptor is coupled to … TNF
receptor to the activation of the transcription factor NF-KB, which represents a major step in TNF …

Through its type 1 receptor (TNFR1), the cytokine TNF elicits an unusually wide range of
biological responses, including inflammation, tumor necrosis, cell proliferation, differentiation, …

… the agonistic antibody htr9 activated NF-KB via the type B TNF receptor (see above). Thus,
triggering of the type B TNF receptor is necessary and sufficient for activation of NF -KB. In …