… in the genesis of cancer and our review has revealed that some tobacco-related DNA
adducts appear to be causally related to some tobacco-related cancers. However, the data are …

… formation of tobacco smoke-related DNA adducts in humans (… 2) newly characterized DNA
adducts formed by tobacco-specific … of applying DNA adducts as biomarkers of tobacco smoke …

… of DNA adducts in tobacco carcinogenesis include numerous studies showing associations
of tobacco smoke exposure with the induction of DNA adducts … smoking and DNA adducts in …

… such as the level of DNA adducts. Of more immediate interest is the … in tobacco smoke that
initiate cancer in humans by characterizing the DNA adducts formed in the tissuesof smokers. …

… Tobacco smoke contains many carcinogens that exert their … of reactive intermediates with
DNA to form DNA adducts. The same … of DNA adducts in tissues not directly exposed to tobacco …

… Thus, this article reviews the newest literature on DNA adducts and DNA repair inhibition
induced by nicotine and ECAs in mice and cultured human cells, and provides insights into …

… genotoxic components of tobacco smoke, which give rise to DNA damage in the tissue, and
while it does not prove causality, it gives credence to the potential for tobacco smoking to be …

… As shown in Table 1, there are a number of other types of DNA adducts derived from agents
in tobacco smoke that also can give rise to G to T transversions. These include apurinic sites …

… Since the major site of tobacco smoke induced cancer is the lung, we chose this tissue to
study the formation of tobaccospecific nitrosamine-DNA adducts. DNA samples were obtained …

… Consequently, tobacco-specific nitrosamines can contribute to background DNA adduct
formation. This paper will describe DNA adduct formation from tobacco-specific nitrosamines. …