Reduced mortality in cystic fibrosis patients treated with tobramycin inhalation solution

GS Sawicki, JE Signorovitch, J Zhang… - Pediatric …, 2012 - Wiley Online Library
tobramycin inhalation solution has been used for over a decade to improve lung function and
reduce exacerbations in patients with cystic fibrosis … use of tobramycin inhaled solution and …

Long-term safety and efficacy of tobramycin in the management of cystic fibrosis

E Vázquez-Espinosa, RM Girón… - … and clinical risk …, 2015 - Taylor & Francis
… as an inhaled parenteral solution. Subsequently, a specific tobramycin inhalation solution was
… gold standard efficacy and safety with tobramycin in cystic fibrosis) compared TIP with TIS. …

Duration of treatment effect after tobramycin solution for inhalation in young children with cystic fibrosis

RL Gibson, J Emerson, N Mayer‐Hamblett… - Pediatric …, 2007 - Wiley Online Library
… Significant microbiologic effect of inhaled tobramycin in young children with cystic fibrosis: a
… treatment effect of inhaled tobramycin in young children with cystic fibrosis. Pediatr Pulmonol…

Tobramycin solution for inhalation in cystic fibrosis patients: a review of the literature

JK Hagerman, SA Knechtel… - Expert Opinion on …, 2007 - Taylor & Francis
… binding of tobramycin to mucin in the sputum of cystic fibrosis patients, … It is also important to
note that cystic fibrosis patients are … with respect to tobramycin MIC. One study demonstrated …

Efficiency of pulmonary administration of tobramycin solution for inhalation in cystic fibrosis using an improved drug delivery system

DE Geller, M Rosenfeld, DA Waltz, RW Wilmott… - Chest, 2003 - Elsevier
Study objectives To determine whether tobramycin solution for inhalation (TSI) can be
administered safely and more efficiently with a new-generation aerosol device, the AeroDose 5.5 …

Clinical use of tobramycin inhalation solution (TOBI®) shows sustained improvement in FEV1 in cystic fibrosis

MW Konstan, JS Wagener, DJ Pasta… - Pediatric …, 2014 - Wiley Online Library
… Clinical trials of tobramycin inhalation solution (TIS; TOBI®) in patients with cystic fibrosis
(CF) with chronic Pseudomonas aeruginosa infection have shown acute improvement in lung …

Treatment with tobramycin solution for inhalation reduces hospitalizations in young CF subjects with mild lung disease

TD Murphy, RD Anbar, LA Lester, SZ Nasr… - Pediatric …, 2004 - Wiley Online Library
… Our objective was to study the effect of tobramycin solution for inhalation (TSI; TOBI®, Chiron
Corp.) on lung function decline rate in 400 young persons with cystic fibrosis (CF) and mild …

Tobramycin administered by the TOBI® Podhaler® for persons with cystic fibrosis: a review

DR VanDevanter, DE Geller - Medical Devices: Evidence and …, 2011 - Taylor & Francis
… III CF studies of tobramycin inhalation solution (TIS), (TOBI ® ; Novartis, Basel, Switzerland),
the delivery system consisted of 5 mL of a 60 mg/mL tobramycin solution loaded into a LC ® …

Efficacy of aerosolized tobramycin in patients with cystic fibrosis

BW Ramsey, HL Dorkin, JD Eisenberg… - … England Journal of …, 1993 - Mass Medical Soc
cystic fibrosis and randomly assigned to one of two crossover regimens. Group 1 received
600 mg of aerosolized tobramycin … for 28 days, followed by tobramycin for two 28-day periods. …

Mortality of cystic fibrosis patients treated with tobramycin solution for inhalation

KJ Rothman, CE Wentworth III - Epidemiology, 2003 - journals.lww.com
… We used the Cystic Fibrosis Foundation registry data to conduct a retrospective cohort study
of the risk of death among cystic fibrosis patients in 1999 according to their use of TSI during …