[HTML][HTML] Tocilizumab in patients hospitalised with COVID-19 pneumonia: Efficacy, safety, viral clearance, and antibody response from a randomised controlled trial …

IO Rosas, N Bräu, M Waters, RC Go, A Malhotra… - …, 2022 - thelancet.com
… -CoV-2 viral load, standard-of-care medications, and patient … the effect of tocilizumab on viral
clearance and host immune … with tocilizumab did not delay SARS-CoV-2 viral clearance or …

[HTML][HTML] Impact of interleukin-6 blockade with tocilizumab on SARS-CoV-2 viral kinetics and antibody responses in patients with COVID-19: A prospective cohort study

M Masiá, M Fernández-González, S Padilla… - …, 2020 - thelancet.com
viral clearance is delayed in patients receiving tocilizumab, this effect is mainly driven by
the initial viral … Our results can also be extrapolated to patients receiving tocilizumab for …

[HTML][HTML] Tocilizumab in patients with severe COVID-19: a retrospective cohort study

G Guaraldi, M Meschiari, A Cozzi-Lepri… - The Lancet …, 2020 - thelancet.com
… storm, treatment with tocilizumab appeared to have clinical … higher in patients without
tocilizumab than in the tocilizumab group (72… effect of tocilizumab compared with standard of care. …

[HTML][HTML] Utilizing tocilizumab for the treatment of cytokine release syndrome in COVID-19

A Hassoun, ED Thottacherry, J Muklewicz… - Journal of Clinical …, 2020 - ncbi.nlm.nih.gov
… There are concerns regarding the risk of infection as well as theoretically delaying viral
clearance [2,5]. Our patients were screened for … Viral clearance was not assessed in our patients. …

Determinants of prolonged viral RNA shedding in hospitalized patients with SARS-CoV-2 infection

FC Dezza, A Oliva, F Cancelli, G Savelloni… - … and infectious disease, 2021 - Elsevier
… Univariate analyses showed that age, male gender, receiving corticosteroids, receiving
tocilizumab, ICU admission, low albumin and NLR ratio were associated with late viral clearance

Short‐course tocilizumab increases risk of hepatitis B virus reactivation in patients with rheumatoid arthritis: a prospective clinical observation

LF Chen, YQ Mo, J Jing, JD Ma… - … journal of rheumatic …, 2017 - Wiley Online Library
… in RA patients with chronic HBV infection, but in this study patients remained asymptomatic
and had a benign outcome after antiviral treatment. To identify the exact risk of TCZ on HBV …

[HTML][HTML] Early use of low dose tocilizumab in patients with COVID-19: a retrospective cohort study with a complete follow-up

N De Rossi, C Scarpazza, C Filippini, C Cordioli… - …, 2020 - thelancet.com
… of tocilizumab patients as compared to controls (multivariate HR for death: 0.057; 95% CI
= 0.017- 0.187, p < 0.001, Fig. 1). The data revealed that the risk of death increases by 6% for …

[HTML][HTML] Efficacy and safety of tocilizumab in COVID-19 patients

KL Zheng, Y Xu, YF Guo, L Diao, XY Kong… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
… may have a negative effect on viral clearance [29]. In the present … tocilizumab-treated and
conventionally treated patients (22.4 vs. 18.8, P=0.184). The dose and frequency of tocilizumab

Tocilizumab for treatment of mechanically ventilated patients with COVID-19

EC Somers, GA Eschenauer, JP Troost… - Clinical Infectious …, 2021 - academic.oup.com
… of viral myocarditis [15] and candidemia [16] with tocilizumab … IL-6 blockade with tocilizumab
is considered for patients with … of usage occurring in patients requiring mechanical ventilation…

Tocilizumab in hospitalized patients with COVID‐19: clinical outcomes, inflammatory marker kinetics, and safety

JA Hill, MP Menon, S Dhanireddy… - Journal of medical …, 2021 - Wiley Online Library
… control for many viral infections, but overproduction of IL-6 may be detrimental to viral
clearance and survival. Results from a randomized controlled trial indicate that tocilizumab did not …