… -associated TIA-1 and TIAR proteins as key regulators of 5′TOP mRNA translation during
amino acid starvation. TIA-1 and TIAR interact specifically with the 5′ end of 5′TOP mRNAs …

… This study also reveals that TIA-1/TIAR-dependent regulation of 5′TOP mRNA
translation requires both activation by GCN2 kinase and inactivation of mTOR signaling (Fig. …

… that TIA-1 repressed the translation of bound mRNAs. In summary, we report a signature
motif present in mRNAs that associate with TIA-1 and provide support to the notion that TIA-1 …

… -promoting protein TIA-1 regulates alternative pre-mRNA splicing of the … TIA-1 associates
selectively with pre-mRNAs that contain 5′ splice sites followed by U-rich sequences. TIA-1 …

… As TIA-1 is a translational silencer and PABP-I a translational enhancer, we favor the …
mRNA triage domains where mRNAs are converted to silenced mRNPs by the addition of TIA-1. …

… targeted translationally stalled mRNAs into SGs limits the … antigen (TIA) proteins (TIA-1 and
TIA-1 related protein (TIAR))… in which TIA proteins target specific mRNA, and how TIA self-…

… explain the increased expression of apobec-1 mRNA in cells lacking TIA-1, this analysis
reveals that TIA-1 directly or indirectly promotes the decay of apobec-1 mRNA in these cells. …

… we have identified the mRNA targets of Tia1 in activated B lymphocytes. Tia1 protein
accumulates in SGs and is associated with translationally silenced mRNAs including that encoding …

… In combination with RRM2 and in the context of full-length TIA-1, … TIA-1 binding to C-rich
stretches, that are abundant at the 5′ TOPs (5′ terminal oligopyrimidine tracts) of mRNAs …

… that TIA-1 interacts with … TIA-1 to the AU-rich cis element in COL2A1 pre-mRNA was confirmed
by the ribonucleoprotein immunoprecipitation assay. Importantly, we also show that TIA-1 …