… of risk assessment. The evaluation is based on information obtained from 2-year
laboratory-animal studies … carcinogenicity studies exhibited the types of target organ toxicity that …

… methods for evaluating the potential risks of increased human … of in vitro toxicity studies in
risk assessment procedures of … studies to be used as validated tools within risk assessment …

… Below, we review the applications of liver OoC in drug toxicity studies. We have also
summarized in Table 1 the main liver OoC models reported for drug toxicity studies. …

… toxicity studies for health risk assessment consists of a two-tiered approach for evaluating the
reliability of studies … in vivo ecotoxicity studies for environmental risk assessment consists of …

… will transform the ways toxicity testing and chemical risk assessment are conducted, moving
… toxicity pathways using in vitro tests in human cells and cell lines. Population-based studies …

… Central to this vision are (a) “toxicity pathways” (the innate … prototype toxicity pathways to
develop case studies showing … for toxicity testing might be applied to the toxicity pathways …

… Developmental toxicity studies in rodents play an important … developmental toxicity, and how
to perform a risk assessment. … important endpoints for assessing developmental toxicity (US …

… The Science in Risk Assessment and Policy (SciRAP) web-… and toxicity studies for hazard
and risk assessment of chemicals… individual studies. The SciRAP method for evaluating in vivo …

… risk assessment process exist. In order to begin to test the process, we have taken the
approach of examining a prototype toxicity … of a pathway based risk assessment for a specific …

… This article considers the implications of these studies and develops a new, data-driven
tiered toxicity testing framework with potentially broad, international application across multiple …