… survival rates of patients diagnosed with lung cancer, a deeper understanding of the major
molecular alterations that occur in lung cancer, including TP53 gene mutation, is needed. …

… TP53 as a marker for early detection and prognosis and as a therapeutic option. We summarize
recent knowledge of TP53 in lung cancer … mutational pattern of TP53 by analyzing the …

… KRAS or TP53 mutations in a consecutive large cohort of patients with lung adenocarcinoma,
… examined for EGFR, KRAS, and TP53 mutations among a large cohort of patients with lung …

… We retrospectively probed our institutional lung cancer database for tumors with EGFR
kinase domain mutations that were also evaluated by more comprehensive molecular profiling, …

… former smokers with lung adenocarcinomas. We also demonstrate that concurrent TP53
mutation is associated with poorer survival among lung adenocarcinoma patients with EGFR, …

… mutation in the TP53 gene results in a base change in both DNA strands with, for example,
a G→T mutation … spectra in lung adenocarcinomas in smokers and non-smokers. The plot of …

… TP53 missense mutations account for most TP53 mutations in lung adenocarcinomas and
can result in the accumulation of mutant p53 due to increased protein stability. In addition, …

… with somatic TP53 mutation frequency in lung tumours. … TP53 mutation and TP53 haplotypes
in assessing the prognostic and predictive significance of TP53 gene status in lung cancer. …

… display mutations and copy number alterations in KRAS and STK11. In contrast, lung
adenocarcinomas with primarily solid architecture and enrichment for TP53 and NF1 mutations and …

… In conclusion, the presence of p53 gene mutations in NSCLC patients may be independently
associated with a shortened survival and may be somewhat more prognostic in patients …