TP53 mutations in nonsmall cell lung cancer
A Mogi, H Kuwano - BioMed Research International, 2011 - Wiley Online Library
… survival rates of patients diagnosed with lung cancer, a deeper understanding of the major
molecular alterations that occur in lung cancer, including TP53 gene mutation, is needed. …
molecular alterations that occur in lung cancer, including TP53 gene mutation, is needed. …
The TP53 gene, tobacco exposure, and lung cancer
… TP53 as a marker for early detection and prognosis and as a therapeutic option. We summarize
recent knowledge of TP53 in lung cancer … mutational pattern of TP53 by analyzing the …
recent knowledge of TP53 in lung cancer … mutational pattern of TP53 by analyzing the …
[HTML][HTML] Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma
T Kosaka, Y Yatabe, R Onozato, H Kuwano… - Journal of Thoracic …, 2009 - Elsevier
… KRAS or TP53 mutations in a consecutive large cohort of patients with lung adenocarcinoma,
… examined for EGFR, KRAS, and TP53 mutations among a large cohort of patients with lung …
… examined for EGFR, KRAS, and TP53 mutations among a large cohort of patients with lung …
Mutations in TP53, PIK3CA, PTEN and other genes in EGFR mutated lung cancers: Correlation with clinical outcomes
… We retrospectively probed our institutional lung cancer database for tumors with EGFR
kinase domain mutations that were also evaluated by more comprehensive molecular profiling, …
kinase domain mutations that were also evaluated by more comprehensive molecular profiling, …
The impact of smoking and TP53 mutations in lung adenocarcinoma patients with targetable mutations—the Lung Cancer Mutation Consortium (LCMC2)
… former smokers with lung adenocarcinomas. We also demonstrate that concurrent TP53
mutation is associated with poorer survival among lung adenocarcinoma patients with EGFR, …
mutation is associated with poorer survival among lung adenocarcinoma patients with EGFR, …
Smoking, lung cancers and their TP53 mutations
CS Cooper - Mutagenesis, 2002 - academic.oup.com
… mutation in the TP53 gene results in a base change in both DNA strands with, for example,
a G→T mutation … spectra in lung adenocarcinomas in smokers and non-smokers. The plot of …
a G→T mutation … spectra in lung adenocarcinomas in smokers and non-smokers. The plot of …
Specific TP53 subtype as biomarker for immune checkpoint inhibitors in lung adenocarcinoma
H Sun, SY Liu, JY Zhou, JT Xu, HK Zhang, HH Yan… - …, 2020 - thelancet.com
… TP53 missense mutations account for most TP53 mutations in lung adenocarcinomas and
can result in the accumulation of mutant p53 due to increased protein stability. In addition, …
can result in the accumulation of mutant p53 due to increased protein stability. In addition, …
Prognostic value of TP53, KRAS and EGFR mutations in nonsmall cell lung cancer: the EUELC cohort
…, European Early Lung Cancer Consortium - European …, 2012 - Eur Respiratory Soc
… with somatic TP53 mutation frequency in lung tumours. … TP53 mutation and TP53 haplotypes
in assessing the prognostic and predictive significance of TP53 gene status in lung cancer. …
in assessing the prognostic and predictive significance of TP53 gene status in lung cancer. …
Simplified molecular classification of lung adenocarcinomas based on EGFR, KRAS, and TP53 mutations
… display mutations and copy number alterations in KRAS and STK11. In contrast, lung
adenocarcinomas with primarily solid architecture and enrichment for TP53 and NF1 mutations and …
adenocarcinomas with primarily solid architecture and enrichment for TP53 and NF1 mutations and …
Mutations of the p53 gene as a predictor of poor prognosis in patients with non-small-cell lung cancer
T Mitsudomi, T Oyama, T Kusano… - … the National Cancer …, 1993 - academic.oup.com
… In conclusion, the presence of p53 gene mutations in NSCLC patients may be independently
associated with a shortened survival and may be somewhat more prognostic in patients …
associated with a shortened survival and may be somewhat more prognostic in patients …
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