FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation
T Klein, D Abgottspon, M Wittwer… - Journal of medicinal …, 2010 - ACS Publications
… of the most common infections, particularly affecting women. … We describe the synthesis
and the in vitro/in vivo evaluation … effective treatment of urinary tract infections with a new class …
and the in vitro/in vivo evaluation … effective treatment of urinary tract infections with a new class …
Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens
YS Or, RF Clark, S Wang, DTW Chu… - Journal of medicinal …, 2000 - ACS Publications
… ABT-773 is a member of a new generation of macrolide antibiotics which effectively addresses
the drug-resistance problems associated with the treatment of respiratory tract infections. …
the drug-resistance problems associated with the treatment of respiratory tract infections. …
Rational design strategies for FimH antagonists: new drugs on the horizon for urinary tract infection and Crohn's disease
LK Mydock-McGrane, TJ Hannan… - Expert opinion on drug …, 2017 - Taylor & Francis
… Urinary tract infections (UTIs) are one of the most common infectious diseases worldwide,
with greater than 85% of these infections caused by the gram-negative bacteria, …
with greater than 85% of these infections caused by the gram-negative bacteria, …
Antibacterial data synthesis challenges: a systematic review of treatments for complicated Gram-negative urinary tract infections
R Dillon, J Uyei, R Singh… - Journal of Comparative …, 2021 - becarispublishing.com
Aim: To determine the suitability of network meta-analysis (NMA) using antibacterial treatment
evidence in complicated urinary tract infection. Materials & methods: We conducted a …
evidence in complicated urinary tract infection. Materials & methods: We conducted a …
Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists
O Schwardt, S Rabbani, M Hartmann… - Bioorganic & medicinal …, 2011 - Elsevier
… Recently, we reported the synthesis, the critical … bacterial adhesion in a mouse infection
model. The orally available, … infectives for the effective treatment of urinary tract infections. …
model. The orally available, … infectives for the effective treatment of urinary tract infections. …
Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity
E Chorell, JS Pinkner, G Phan… - Journal of medicinal …, 2010 - ACS Publications
… (2-4) It is estimated that approximately 11 million cases of urinary tract infection (UTI a ) …
data on second generation compounds that were synthesized via C-2 substitution of the thiazolo …
data on second generation compounds that were synthesized via C-2 substitution of the thiazolo …
Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections
L Mydock-McGrane, Z Cusumano, Z Han… - Journal of medicinal …, 2016 - ACS Publications
… ) bacteria are a causative pathogen of urinary tract infections (UTIs). Previously developed
… We report on the design, synthesis, and in vivo evaluation of this promising new class of …
… We report on the design, synthesis, and in vivo evaluation of this promising new class of …
Design and creativity in synthesis of multivalent neoglycoconjugates
YM Chabre, R Roy - Advances in carbohydrate chemistry and biochemistry, 2010 - Elsevier
… considerable creativity in the design and synthetic strategies … of glycocluster and
glycodendrimer synthesis follows, starting … synthesized using either divergent or convergent …
glycodendrimer synthesis follows, starting … synthesized using either divergent or convergent …
[PDF][PDF] Synthesis of novel types of polyester glycodendrimers as potential inhibitors of urinary tract infections
B Grindley, N Paul - New J. Chem, 2015 - academia.edu
… as potential inhibitors of uropathogenic Escherichia coli (UPEC) include the use of nontoxic
and biocompatible polyester dendrimer backbones, aglycones whose lengths are designed …
and biocompatible polyester dendrimer backbones, aglycones whose lengths are designed …
A Synthetic Peptide 2Abz23S29 Reduces Bacterial Titer and Induces Pro-Inflammatory Cytokines in a Murine Model of Urinary Tract Infection
… One of the most prevalent sites of bacterial infection in humans is the urinary tract. … tract
infection (UTI) during their lifetimes that a quarter of these people are at risk of becoming infected …
infection (UTI) during their lifetimes that a quarter of these people are at risk of becoming infected …
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