A genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits

Y Guo, B Tomlinson, T Chu, YJ Fang, H Gui, CS Tang… - PloS one, 2012 - journals.plos.org
… of significant association, it suggests that the putative locus is not the functional gene, but
rather is a locus in disequilibrium with a trait locus. In contrast, if the linkage signal disappears …

Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes

MJE van Rijn, AFC Schut, YS Aulchenko… - Journal of …, 2007 - journals.lww.com
… of the trait. We identified significant (environmental) covariates for each blood pressure
trait in order to estimate the contribution of environmental factors to blood pressure variance. …

Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22.

DA Wu, X Bu, CH Warden, DD Shen… - The Journal of …, 1996 - Am Soc Clin Investig
… The underlying trait can follow either Mendelian or non-Mendelian modes of … traits such
as systolic blood pressure and diastolic blood pressure against various candidate gene loci. A …

Recent findings in the genetics of blood pressure and hypertension traits

N Franceschini, AP Reiner… - American journal of …, 2011 - academic.oup.com
… Sex-specific quantitative trait loci have been described for BP traits. In contrast, BP-associated
SNPs identified in recent GWAS by Global BPgen did not show evidence for sex-specific …

Genome-wide variance quantitative trait locus analysis suggests small interaction effects in blood pressure traits

G Shi - Scientific Reports, 2022 - nature.com
… with systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP).
The … their regulatory roles in mediating the associations with blood pressure (BP). Of the 27 …

New blood pressure–associated loci identified in meta-analyses of 475 000 individuals

AT Kraja, JP Cook, HR Warren… - Circulation …, 2017 - Am Heart Assoc
… ; trait, the blood pressure trait (diastolic blood pressure, systolic blood pressure, or pulse
pressure) … rare variants influencing blood pressure and overlapping with metabolic trait loci.Nat …

Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations

J Liang, TH Le, DRV Edwards, BO Tayo… - PLoS …, 2017 - journals.plos.org
… We conducted a genome-wide association study of blood pressure in 31,968 … blood
pressure. This research identified three novel genomic regions associated with blood pressure

Positional cloning of quantitative trait Loci for blood pressure: how close are we? a critical perspective

AY Deng - Hypertension, 2007 - Am Heart Assoc
… 3 To alleviate the drawbacks of human investigations, animal models, especially inbred
rodents, have been developed and experimentally manipulated to identify quantitative trait loci (…

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

C Liu, AT Kraja, JA Smith, JA Brody, N Franceschini… - Nature …, 2016 - nature.com
… We considered the aggregate effects of the blood pressure loci on blood pressure–related
clinical outcomes using new Exome Chip–based results for coronary artery disease (CAD) …

Identification of blood pressure quantitative trait loci that differentiate two hypertensive strains

MR Garrett, B Joe, H Dene, JP Rapp - Journal of hypertension, 2002 - journals.lww.com
… This study was also informative and showed that S and SHR bear contrasting blood
pressure alleles at three quantitative trait loci (QTL) on rat chromosomes (RNO) 3, 8 and 9 [ 2 ]. …