A genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits
… of significant association, it suggests that the putative locus is not the functional gene, but
rather is a locus in disequilibrium with a trait locus. In contrast, if the linkage signal disappears …
rather is a locus in disequilibrium with a trait locus. In contrast, if the linkage signal disappears …
Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes
MJE van Rijn, AFC Schut, YS Aulchenko… - Journal of …, 2007 - journals.lww.com
… of the trait. We identified significant (environmental) covariates for each blood pressure
trait in order to estimate the contribution of environmental factors to blood pressure variance. …
trait in order to estimate the contribution of environmental factors to blood pressure variance. …
Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22.
DA Wu, X Bu, CH Warden, DD Shen… - The Journal of …, 1996 - Am Soc Clin Investig
… The underlying trait can follow either Mendelian or non-Mendelian modes of … traits such
as systolic blood pressure and diastolic blood pressure against various candidate gene loci. A …
as systolic blood pressure and diastolic blood pressure against various candidate gene loci. A …
Recent findings in the genetics of blood pressure and hypertension traits
N Franceschini, AP Reiner… - American journal of …, 2011 - academic.oup.com
… Sex-specific quantitative trait loci have been described for BP traits. In contrast, BP-associated
SNPs identified in recent GWAS by Global BPgen did not show evidence for sex-specific …
SNPs identified in recent GWAS by Global BPgen did not show evidence for sex-specific …
Genome-wide variance quantitative trait locus analysis suggests small interaction effects in blood pressure traits
G Shi - Scientific Reports, 2022 - nature.com
… with systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP).
The … their regulatory roles in mediating the associations with blood pressure (BP). Of the 27 …
The … their regulatory roles in mediating the associations with blood pressure (BP). Of the 27 …
New blood pressure–associated loci identified in meta-analyses of 475 000 individuals
AT Kraja, JP Cook, HR Warren… - Circulation …, 2017 - Am Heart Assoc
… ; trait, the blood pressure trait (diastolic blood pressure, systolic blood pressure, or pulse
pressure) … rare variants influencing blood pressure and overlapping with metabolic trait loci.Nat …
pressure) … rare variants influencing blood pressure and overlapping with metabolic trait loci.Nat …
Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations
J Liang, TH Le, DRV Edwards, BO Tayo… - PLoS …, 2017 - journals.plos.org
… We conducted a genome-wide association study of blood pressure in 31,968 … blood
pressure. This research identified three novel genomic regions associated with blood pressure …
pressure. This research identified three novel genomic regions associated with blood pressure …
Positional cloning of quantitative trait Loci for blood pressure: how close are we? a critical perspective
AY Deng - Hypertension, 2007 - Am Heart Assoc
… 3 To alleviate the drawbacks of human investigations, animal models, especially inbred
rodents, have been developed and experimentally manipulated to identify quantitative trait loci (…
rodents, have been developed and experimentally manipulated to identify quantitative trait loci (…
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci
… We considered the aggregate effects of the blood pressure loci on blood pressure–related
clinical outcomes using new Exome Chip–based results for coronary artery disease (CAD) …
clinical outcomes using new Exome Chip–based results for coronary artery disease (CAD) …
Identification of blood pressure quantitative trait loci that differentiate two hypertensive strains
MR Garrett, B Joe, H Dene, JP Rapp - Journal of hypertension, 2002 - journals.lww.com
… This study was also informative and showed that S and SHR bear contrasting blood
pressure alleles at three quantitative trait loci (QTL) on rat chromosomes (RNO) 3, 8 and 9 [ 2 ]. …
pressure alleles at three quantitative trait loci (QTL) on rat chromosomes (RNO) 3, 8 and 9 [ 2 ]. …
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