Impact of cytosine methylation on DNA binding specificities of human transcription factors

Y Yin, E Morgunova, A Jolma, E Kaasinen, B Sahu… - Science, 2017 - science.org
… the effect of cytosine methylation on transcription factor binding… transcription factors and
extended DNA binding domains to unmethylated and CpG-methylated DNA by using methylation

Effects of cytosine methylation on transcription factor binding sites

YA Medvedeva, AM Khamis, IV Kulakovskiy… - BMC genomics, 2014 - Springer
methylation in promoters is closely linked to downstream gene repression. However, whether
DNA methylation … , then DNA methylation may affect the affinity of transcription factors (TFs) …

The effects of cytosine methylation on general transcription factors

J Jin, T Lian, C Gu, K Yu, YQ Gao, XD Su - Scientific reports, 2016 - nature.com
methylation effects on DNA/protein interactions, we have chosen three human transcription
factors … estrogen receptor (ER) with methylated or unmethylated DNA binding sequences, …

Cytosine methylation does not affect binding of transcription factor Sp1.

MA Harrington, PA Jones… - Proceedings of the …, 1988 - National Acad Sciences
… investigate the effect of cytosine methylation on the binding of the transcription factor Spl to
… The results therefore preclude a direct effect of cytosine methylation on Spl-DNA interactions…

Toward a base-resolution panorama of the in vivo impact of cytosine methylation on transcription factor binding

A Hernandez-Corchado, HS Najafabadi - Genome Biology, 2022 - Springer
Transcription factors (TFs) are key regulators of gene expression. Each TF usually … , among
which cytosine methylation is traditionally viewed as having a repressive effect on TF binding […

Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter.

F Watt, PL Molloy - Genes & development, 1988 - genesdev.cshlp.org
… examined whether methylation of CpG dinucleotides located within the binding site for a
specific transcription factor, MLTF or USF, affects its binding to DNA. This HeLa cell factor binds …

Cytosine methylation of mitochondrial DNA at CpG sequences impacts transcription factor A DNA binding and transcription

V Dostal, MEA Churchill - Biochimica et Biophysica Acta (BBA)-Gene …, 2019 - Elsevier
… In this study we examined the effects of cytosine methylation of CpG on TFAM DNA binding,
TFAM-dependent DNA compaction and transcription. Quantitative binding experiments …

Quantitative analysis of the DNA methylation sensitivity of transcription factor complexes

JF Kribelbauer, O Laptenko, S Chen, GD Martini… - Cell reports, 2017 - cell.com
effect of cytosine methylation on binding affinity, we developed a feature-based generalized
linear model to estimate the change in binding free energy associated with cytosine

Sensitivity of transcription factors to DNA methylation

É Héberlé, AF Bardet - Essays in biochemistry, 2019 - portlandpress.com
… While the chemical evidence of cytosine methylation was initially discovered in 1948 [16],
the first functional evidence that it could regulate physiological processes emerged in 1975 [17]…

[HTML][HTML] Toward a mechanistic understanding of DNA methylation readout by transcription factors

JF Kribelbauer, XJ Lu, R Rohs, RS Mann… - Journal of molecular …, 2020 - Elsevier
… This review will primarily cover in vitro–based methods that quantify how TFs respond to
cytosine methylation and address to what extent the results of these assays have improved the …