Sensitivity of transcription factors to DNA methylation

É Héberlé, AF Bardet - Essays in biochemistry, 2019 - portlandpress.com
… Although DNA methylation has long been thought to repress TF binding, a more recent …
inhibit DNA methylation. Here, we review the possible scenarios by which DNA methylation and …

Transcription factors as readers and effectors of DNA methylation

H Zhu, G Wang, J Qian - Nature Reviews Genetics, 2016 - nature.com
… also interact with methylated DNA. The … methylation-dependent transcription factorDNA
interactions are important stepping stones towards a mechanistic understanding of methylation-…

Cross-talk between site-specific transcription factors and DNA methylation states

A Blattler, PJ Farnham - Journal of Biological Chemistry, 2013 - ASBMB
… Because DNA methylation is reversible, there is … by DNA-binding transcription factors. We
discuss several models that, by incorporating sequence motifs, CpG density, and methylation

DNA methylation presents distinct binding sites for human transcription factors

S Hu, J Wan, Y Su, Q Song, Y Zeng, HN Nguyen… - elife, 2013 - elifesciences.org
… Because our goal was to identify DNA methylation-dependent binding activity, we developed
a competition assay on a protein microarray to identify TFs that prefer DNA motifs carrying …

On how mammalian transcription factors recognize methylated DNA

BA Buck-Koehntop, PA Defossez - Epigenetics, 2013 - Taylor & Francis
… , DNA methylation regulates gene expression by repressing promoter activity. The repressive
effects of DNA methylation on the … Citation 12 DNA methylation can prevent transcriptional

Emerging concept in DNA methylation: role of transcription factors in shaping DNA methylation patterns

C Marchal, B Miotto - Journal of cellular physiology, 2015 - Wiley Online Library
… In the current review, we will focus our discussion on the role of transcription factors and
signaling pathways in regulating DNA methylation profiles, and their changes in response to …

[PDF][PDF] Role of DNA methylation in modulating transcription factor occupancy

MT Maurano, H Wang, S John, A Shafer, T Canfield… - Cell reports, 2015 - cell.com
… of other regulatory factors. Here we investigate the causal relationship between genomewide
DNA methylation and TF occupancy using the model TF CCCTC-binding factor (zinc finger …

Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation

E Hervouet, FM Vallette, PF Cartron - Epigenetics, 2009 - Taylor & Francis
… sequence for DNA methylation of Dnmt3a is increased in presence of c-myc. By … transcription
factor array spotted with 103 transcription factors, we next identified 79 transcription factors

[PDF][PDF] Quantitative analysis of the DNA methylation sensitivity of transcription factor complexes

JF Kribelbauer, O Laptenko, S Chen, GD Martini… - Cell reports, 2017 - cell.com
… Ligands To quantitatively assess the effects of DNA methylation on TF binding, we
developed a method in which a methylated library (Lib-M) and an unmethylated library (Lib-U) …

DNA methylation and the regulation of gene transcription

JT Attwood, RL Yung, BC Richardson - Cellular and Molecular Life …, 2002 - Springer
… cytosine bases leads to the inaccessibility of DNA regulatory elements to their transcription
factors by a number of mechanisms. Our understanding of DNA methylation has advanced …