… various transferrin forms, but the addition of transferrin-gallium leads to inhibition of … cellular
iron incorporation by transferrin-gallium is a prerequisite for inhibition of cellular proliferation. …

… Finally, the way in which gallium salts are currently being investigated as … transferrin-gallium
effects on cellular proliferation. INTRODUCTION Cell surface receptors for transferrin, the …

… 5 Landschulz W, Thesleff I, Ekblom P: A lipophilic iron chelator can replace transferrin as
a stimulator of cell proliferation and differentiation. J Cell Biol 1984;98:596-601. 6 Larrick JW, …

… more than 10-fold when the gallium is added as transferrin-gallium (13, 18). In … of
transferrin-gallium by demonstrating that inhibition of cellular iron utilization is a prerequisite for …

… [67Ga] bound to transferrin has been isolated from lysates prepared from … ] in the
presence of transferrin, and the same cell surface transferrin receptor is … ferating and non-proliferating …

… We therefore performed studies to determine whether Tf-Ga inhibited T cell proliferation
by interfering with either of these two events. The effect of Tf-Ga on IL-2 secretion was investi…

… of different transferrin forms on transferrin receptor expression, iron uptake, and cellular
proliferation of … Mechanisms responsible for the specific cytotoxicity of transferrin-gallium. J. Clin. …

… that transferrin-gallium inhibits cellular iron incorporation and can thus block the proliferation
… receptor expression, iron uptake, and cellular proliferation of human leukemic HL60 cells. …

… cell associated transferrin receptors. Although the actual mechanism of this is not known, the
evidence suggests that the “Ga-transferrin complex is internalized into the cell, … proliferating …

… roles of transferrin receptor (TfR) targeting and apoptotic pathways in gallium-induced cell
death. … In contrast to the inhibitory effects of gallium nitrate on cell proliferation after 48 and 72 …