… A central event in tissue repair is the release of cytokines in response to injury. Several lines
… to transforming growth factor β (TGF-β) as a key cytokine that initiates and terminates tissue …

… responses have also been implicated in the pathogenesis of fibrosis-associated diseases. …
reparative and fibrotic responses. The notion that TGF-βs mediate tissue fibrosis is supported …

… The net accumulation of collagen in tissue fibrosis is a result of an imbalance between enhanced
… in abnormally elevated synthesis of typeIcollagen which, in turn, causes tissue fibrosis. …

… We have a considerable understanding of the pathophysiological process of tissue fibrosis,
but we are having difficulty identifying anti-fibrosis targets that are successful in clinical …

… of skin fibrosis. The animal model on skin fibrosis by exogenous application of growth
factors developed in this study may prove useful for future studies on fibrotic disorders. J. Cell. …

… A subset of these genes, including the key profibrotic cytokine transforming growth factor beta…
microRNA biology with a focus on their emerging role in diseases typified by organ fibrosis. …

… 13 is a key mediator of tissue fibrosis caused by T helper cell type 2 inflammation. We
hypothesized that the fibrogenic effects of IL-13 are mediated by transforming growth factor (TGF)-β…

… Transforming growth factor (TGF)-β is a prototypic multifunctional cytokine whose broad
modulatory mechanisms affect numerous biological functions both at the cell and organism …

… role in the pathogenesis of skin fibrosis. In the present study, we attempted to establish an
animal model of skin fibrosis by exogeneous applicaTransforming growth factor-b (TGF-b) is a …

… actions of transforming growth factor-β 1 and connective tissue growth factor in renal
fibrosis … Transforming growth factor-β (TGF-β)-neutralizing antibody (aT) inhibits connective …