Toremifene prevents prostate cancer in the transgenic adenocarcinoma of mouse prostate model
S Raghow, MZ Hooshdaran, S Katiyar, MS Steiner - Cancer Research, 2002 - AACR
… levels were elevated in the toremifene-treated group. Toremifene treatment did not affect
androgen receptor levels… free testosterone levels with no change in prostate androgen receptor …
androgen receptor levels… free testosterone levels with no change in prostate androgen receptor …
The insulin-like growth factor axis and prostate cancer: lessons from the transgenic adenocarcinoma of mouse prostate (TRAMP) model
… receptor (IGF1R), a tyrosine kinase transmembrane receptor … as the mannose-6-phosphate
receptor, binds IGF-II but with … a level corresponding to the maximal nontransgenic level by 12 …
receptor, binds IGF-II but with … a level corresponding to the maximal nontransgenic level by 12 …
Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinoma
RA Moorehead, OH Sanchez, RM Baldwin, R Khokha - Oncogene, 2003 - nature.com
… Elevated levels of insulin-like growth factor (IGF)-II are associated with a poor prognosis in
… -II in pulmonary adenocarcinoma has not been demonstrated. Here, we show that transgenic …
… -II in pulmonary adenocarcinoma has not been demonstrated. Here, we show that transgenic …
Trans-complementation of vector replication versus Coxsackie-adenovirus-receptor overexpression to improve transgene expression in poorly permissive cancer cells
H Fechner, X Wang, H Wang, A Jansen… - Gene Therapy, 2000 - nature.com
… the transgene expression level beyond the step of receptor-mediated AdV uptake.
Nevertheless, AdV uptake was positively correlated with CAR, but not with α v β 3 and α v β 5 …
Nevertheless, AdV uptake was positively correlated with CAR, but not with α v β 3 and α v β 5 …
Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor
JM Carboni, AV Lee, DL Hadsell, BR Rowley, FY Lee… - Cancer research, 2005 - AACR
… Transgenic mice that expressed the activated receptor … developed salivary and mammary
adenocarcinomas as early as … had particularly high levels of transgene expression developed …
adenocarcinomas as early as … had particularly high levels of transgene expression developed …
Regression of mouse prostatic intraepithelial neoplasia by nonsteroidal anti-inflammatory drugs in the transgenic adenocarcinoma mouse prostate model
BA Narayanan, NK Narayanan, B Pittman… - Clinical Cancer …, 2004 - AACR
… Experimental Design: We used the transgenic mouse … stage to adenocarcinoma, and
metastasis by a transgene that is … measure the level of expression of androgen receptor, vascular …
metastasis by a transgene that is … measure the level of expression of androgen receptor, vascular …
Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model: A good alternative to study PCa progression and chemoprevention approaches
… that AR and estrogen receptor α (ERα) levels tend to increase in the … adenocarcinoma in
comparison with wild mice. Also, a reduced incidence of poorly differentiated adenocarcinoma …
comparison with wild mice. Also, a reduced incidence of poorly differentiated adenocarcinoma …
Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells
A Kanerva, GV Mikheeva, V Krasnykh… - Clinical Cancer …, 2002 - AACR
… adenocarcinoma cell lines and primary human ovarian cancer cells. Also, our results suggest
correlation between transgene transfer and receptor … that the level of Ad3 receptor would …
correlation between transgene transfer and receptor … that the level of Ad3 receptor would …
Transgenic mice reveal roles for TGFα and EGF receptor in mammary gland development and neoplasia
JA Schroeder, DC Lee - Journal of mammary gland biology and neoplasia, 1997 - Springer
… prolactin receptor levels in MMTV-TGFa transgenic and control … significantly blunted in the
transgenic mice. Although serum … of mammary adenocarcinoma in transgenic mice bearing the …
transgenic mice. Although serum … of mammary adenocarcinoma in transgenic mice bearing the …
Induction of lung adenocarcinoma in transgenic mice expressing activated EGFR driven by the SP‐C promoter
K Ohashi, K Rai, Y Fujiwara, M Osawa… - Cancer …, 2008 - Wiley Online Library
… receptor (EGFR) mutation in lung cancer, we generated … the level of EGFR mRNA expression
in the lungs of transgenic … to the level in the normal lungs of non-transgenic mice (Fig. 2e). …
in the lungs of transgenic … to the level in the normal lungs of non-transgenic mice (Fig. 2e). …
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