… of human prostate cancer. To this end, we initiated a research program to establish a
transgenic animal model for prostate cancer byusing a prostate-specific transgene expression …

… regulators, and tumor suppressor genes have been used. Such models have contributed …
In particular, the transgenic mouse models based on multiple genetic alterations can more …

… is hormonally regulated by androgens, thus temporally, transgene expression … of transgene
expression, we have demonstrated that TRAMP mice develop progressive prostate cancer …

… has been slow, largely due to the scarcity of adequate animal model systems that … Prostate
cancer in a transgenic mouse. A) Gross pathology of prostate in a male TRAMP mouse at 27 …

… to the prostate epithelium facilitated development of an autochtonous inbred transgenic
mouse model for prostate cancer (6). In this model, henceforth referred to as the TRAMP model, …

… Purpose: Transgenic mouse models are proving to be invaluable in our effort to understand
… of metastatic prostate cancer (CaP). We review and discuss how current animal models have …

… This complexity can be mimicked closely by transgenic animal models that incorporate the
… associated with cancer progression. Transgenic animal models for human cancer allow us to …

… , a method that does not reproduce the natural development of the tumor, both for the … T-antigen-transgenic
mouse model of prostate cancer in which the tumor spontaneously develops …

… these mouse models include overexpression of the transgene, knock-out/knock-in of transgene
… have been utilized to create genetically engineered mouse models for PCa. Furthermore, …

… The Prostate Cancer Foundation held a Prostate Cancer Models … the state of prostate cancer
preclinical models and identified … , xenograft and genetically engineered mouse models that …