Recent progress in the use of mitochondrial membrane permeability transition pore in mitochondrial dysfunction-related disease therapies

Y Cui, M Pan, J Ma, X Song, W Cao… - Molecular and Cellular …, 2021 - Springer
… and summarizes the mitochondrial dysfunction-correlated diseases and … mitochondrial
dysfunction, this review also summarizes potential treatments, which may be used to inhibit pore

Mitochondria and aging: A role for the mitochondrial transition pore?

M Panel, B Ghaleh, D Morin - Aging cell, 2018 - Wiley Online Library
… features of mitochondrial physiology and dysfunction have been … role of the mitochondrial
permeability transition pore (mPTP) in … , thus reinforcing mitochondrial dysfunction (Figure 2). …

[HTML][HTML] Diabetes Mellitus, Mitochondrial Dysfunction and Ca2+-Dependent Permeability Transition Pore

KN Belosludtsev, NV Belosludtseva… - International journal of …, 2020 - mdpi.com
… the role of mitochondrial dysfunction in the development of … of mitochondrial calcium
transport systems and a pathophysiological phenomenon called the permeability transition pore in …

[HTML][HTML] Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle

EP Taddeo, RC Laker, DS Breen, YN Akhtar… - Molecular …, 2014 - Elsevier
mitochondrial permeability transition pore (mPTP). The mPTP is a multi-protein complex that
spans both mitochondrial … Da between the cytoplasm and mitochondrial matrix. Importantly, …

[HTML][HTML] Mitochondrial dysfunction and alterations in mitochondrial permeability transition pore (mPTP) contribute to apoptosis resistance in idiopathic pulmonary …

ER Luis-García, C Becerril, A Salgado-Aguayo… - International journal of …, 2021 - mdpi.com
… To investigate whether apoptosis resistance in IPF fibroblasts is associated with mitochondrial
dysfunction, we analyzed the integrity of mitochondria through oxygen consumption in IPF …

[HTML][HTML] Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease

MJ Pérez, DP Ponce, A Aranguiz, MI Behrens… - Redox Biology, 2018 - Elsevier
mitochondrial calcium uptake by the mitochondrialmitochondrial failure in AD fibroblasts.
These findings suggest that peripheral cells present similar signs of mitochondrial dysfunction

The molecular composition of the mitochondrial permeability transition pore

CP Baines - Journal of molecular and cellular cardiology, 2009 - Elsevier
… The discovery that mitochondrial dysfunction is often a … studying the mitochondrial permeability
transition pore and its … molecular composition of the mitochondrial pore, and the purpose …

[HTML][HTML] The mitochondrial permeability transition pore in AD 2016: An update

L Biasutto, M Azzolini, I Szabo, M Zoratti - Biochimica et Biophysica Acta …, 2016 - Elsevier
… Paraplegia 7 (SPG7), a mitochondrial AAA-type membrane protease which forms … mitochondrial
permeability transition pore. This article is part of a Special Issue entitled: Mitochondrial

Physiological roles of the permeability transition pore

C Brenner, M Moulin - Circulation research, 2012 - Am Heart Assoc
… homeostasis is tightly regulated, and mitochondrial dysfunction is frequently associated with
severe human pathologies (eg, cardiovascular diseases, cancer, and neurodegeneration). …

[HTML][HTML] Physiopathology of the permeability transition pore: Molecular mechanisms in human pathology

M Bonora, S Patergnani, D Ramaccini, G Morciano… - Biomolecules, 2020 - mdpi.com
… When mitochondria are exposed to a pathological overload of … of the mitochondrial
permeability transition pore complex (… Recently, mitochondrial dysfunction has been increasingly …