… tumor evolution and heterogeneity, and the potential and challenges for translating the
insights … We discuss how tumor evolution can guide cancer therapy by targeting clonal and …

… likely to be lost during tumor evolution and may drive sustained tumor elimination in the tumor
… at serial time points during ICI provide insights into tumor burden kinetics and enable the …

… tumors has revealed novel insights into oncogenic mechanisms. In particular, we highlight
the remarkable insight … evolution of the tumor and to lead subsequently to genomic instability. …

… Past successes in converting information from genomic discoveries into clinical tools provide
valuable lessons to guide the translation of emerging insights from the genome into clinical …

… level of research are easily translated through cross-species … human studies can also be
translated back to improve survival … are able utilize these evolutionary insights to generate and …

… The evaluation process recommended in this report (Figure S-1) defines the best practices
for translation of an omics-based discovery into a validated omics-based test for use in a …

… key insights into key mutational events promoting tumor … in murine studies fail to translate
into successful clinical trials … in tumor cells within a single tumor as tumor cells evolve (40)…

… -like models can this translation paradigm be enhanced? How can insights from in vitro
models … models of evolution need to be developed for addressing evolutionary trajectories and …

… will provide insight into the dynamics of tumor cell dissemination … Tumor heterogeneity and
the evolution of highly metastatic subclones during the progression of heterogeneous tumors …

… What matters is that emerging challenges are recognised early, and lessons and insights
gained from the past are rapidly and effectively translated into the oncology clinic. This will …