… the drug 4 -iodo-4 -deoxydoxorubicin (I-DOX) on the in vitro assembly of TTR Leu55Pro fibrils
… However, after 15 days of treatment, only round particles, resembling soluble native TTR, …

… The data presented in this study clearly show that I-DOX binds specifically to TTR amyloid
fibrils in tissues from patients with FAP. I-DOX staining does co-localize with TTR amyloid as …

… Leu-55Pro TTR–IDOX model in TTR amyloidosis, since there … Leu-55Pro TTR amyloid-like
structure (Table 1 and Figure 4). … to TTR oligomers, in particular to the Leu-55Pro TTR amyloid-…

… 4’-Iodo-4’deoxydoxorubicin disrupts the fibrillar structure of transthyretin amyloid. Am
JPathol 156, 1919-1925 Sebastiiio MP, Merlini G, Saraiva MJ and Damas AM (2000). …

… 4'-iodo-4'-deoxydoxorubicin (IDOX) can induce amyloid resorption in patients with
immunoglobulin light chain amyloidosis … amyloid fibrils tested: immunoglobulin light chains, …

… To distinguish SSA from hereditary ATTR amyloidosis, the TTR gene sequence and/or the
shift in molecular mass of TTR should be analyzed in all cases with TTR amyloid deposits. 4. …

… for TTR amyloid fibril formation we discuss the action of some of the proposed TTR stabilizers
… ) and the action of amyloid disrupters such as 4’-iodo-4’-deoxydoxorubicin (I-DOX) and …

… TTR amyloid fibrils may form because of nucleation-dependent polymerization after LT,
although TTR amyloid … variant TTR gene carriers to prevent TTR amyloid deposition in tissues. …

… with mutated transthyretin amyloidosis (ATTR) amyloidosis has … Transthyretin (TTR)
stabilizers diflunisal and tafamidis … that 4′-iodo-4′-doxydoxorubicin inhibits amyloid formation …

… that 4′-iodo-4′-doxy doxorubicin inhibits amyloid … of TTR, inhibiting aggregation, disrupting
TTR amyloid, and counteracting cellular toxicity are potential therapies for TTR amyloidosis…