4′‐iodo‐4′‐Deoxydoxorubicin and tetracyclines disrupt transthyretin amyloid fibrils in vitro producing noncytotoxic species: screening for TTR fibril disrupters
… the drug 4 -iodo-4 -deoxydoxorubicin (I-DOX) on the in vitro assembly of TTR Leu55Pro fibrils
… However, after 15 days of treatment, only round particles, resembling soluble native TTR, …
… However, after 15 days of treatment, only round particles, resembling soluble native TTR, …
4′-Iodo-4′-deoxydoxorubicin disrupts the fibrillar structure of transthyretin amyloid
… The data presented in this study clearly show that I-DOX binds specifically to TTR amyloid
fibrils in tissues from patients with FAP. I-DOX staining does co-localize with TTR amyloid as …
fibrils in tissues from patients with FAP. I-DOX staining does co-localize with TTR amyloid as …
The molecular interaction of 4′-iodo-4′-deoxydoxorubicin with Leu-55Pro transthyretin 'amyloid-like'oligomer leading to disaggregation
MP Sebastião, G Merlini, MJ SARAIVA… - Biochemical …, 2000 - portlandpress.com
… Leu-55Pro TTR–IDOX model in TTR amyloidosis, since there … Leu-55Pro TTR amyloid-like
structure (Table 1 and Figure 4). … to TTR oligomers, in particular to the Leu-55Pro TTR amyloid-…
structure (Table 1 and Figure 4). … to TTR oligomers, in particular to the Leu-55Pro TTR amyloid-…
A multicenter phase II trial of 4′-iodo-4′-deoxydoxorubicin (IDOX) in primary amyloidosis (AL)
MA Gertz, MQ Lacy, A Dispenzieri, BD Cheson… - Amyloid, 2002 - Taylor & Francis
… 4’-Iodo-4’deoxydoxorubicin disrupts the fibrillar structure of transthyretin amyloid. Am
JPathol 156, 1919-1925 Sebastiiio MP, Merlini G, Saraiva MJ and Damas AM (2000). …
JPathol 156, 1919-1925 Sebastiiio MP, Merlini G, Saraiva MJ and Damas AM (2000). …
Interaction of the anthracycline 4'-iodo-4'-deoxydoxorubicin with amyloid fibrils: inhibition of amyloidogenesis.
G Merlini, E Ascari, N Amboldi… - Proceedings of the …, 1995 - National Acad Sciences
… 4'-iodo-4'-deoxydoxorubicin (IDOX) can induce amyloid resorption in patients with
immunoglobulin light chain amyloidosis … amyloid fibrils tested: immunoglobulin light chains, …
immunoglobulin light chain amyloidosis … amyloid fibrils tested: immunoglobulin light chains, …
Diagnosis and therapeutic approaches to transthyretin amyloidosis
Y Ando, M Ueda - Current medicinal chemistry, 2012 - ingentaconnect.com
… To distinguish SSA from hereditary ATTR amyloidosis, the TTR gene sequence and/or the
shift in molecular mass of TTR should be analyzed in all cases with TTR amyloid deposits. 4. …
shift in molecular mass of TTR should be analyzed in all cases with TTR amyloid deposits. 4. …
Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses
MR Almeida, L Gales, AM Damas… - Current Drug Targets …, 2005 - ingentaconnect.com
… for TTR amyloid fibril formation we discuss the action of some of the proposed TTR stabilizers
… ) and the action of amyloid disrupters such as 4’-iodo-4’-deoxydoxorubicin (I-DOX) and …
… ) and the action of amyloid disrupters such as 4’-iodo-4’-deoxydoxorubicin (I-DOX) and …
[HTML][HTML] Recent advances in transthyretin amyloidosis therapy
M Ueda, Y Ando - Translational neurodegeneration, 2014 - Springer
… TTR amyloid fibrils may form because of nucleation-dependent polymerization after LT,
although TTR amyloid … variant TTR gene carriers to prevent TTR amyloid deposition in tissues. …
although TTR amyloid … variant TTR gene carriers to prevent TTR amyloid deposition in tissues. …
Doxycycline plus tauroursodeoxycholic acid for transthyretin amyloidosis: a phase II study
L Obici, A Cortese, A Lozza, J Lucchetti, M Gobbi… - Amyloid, 2012 - Taylor & Francis
… with mutated transthyretin amyloidosis (ATTR) amyloidosis has … Transthyretin (TTR)
stabilizers diflunisal and tafamidis … that 4′-iodo-4′-doxydoxorubicin inhibits amyloid formation …
stabilizers diflunisal and tafamidis … that 4′-iodo-4′-doxydoxorubicin inhibits amyloid formation …
[HTML][HTML] Clearance of extracellular misfolded proteins in systemic amyloidosis: experience with transthyretin
MR Almeida, MJ Saraiva - FEBS letters, 2012 - Elsevier
… that 4′-iodo-4′-doxy doxorubicin inhibits amyloid … of TTR, inhibiting aggregation, disrupting
TTR amyloid, and counteracting cellular toxicity are potential therapies for TTR amyloidosis…
TTR amyloid, and counteracting cellular toxicity are potential therapies for TTR amyloidosis…