… The diameter (65 A ) of the protofilament in the model of transthyretin amyloid [23] is very
similar to the dimension of the cross-section of the TTR molecule in the direction perpendicular …

… mutations have been associated with autosomal dominant amyloidosis, usually presenting …
in TTR amyloidosis include: molecular mechanisms leading to fibril formation; mechanisms of …

… The molecular basis underlying the vastly different fibrillation behaviours of these TTR …
Considerable effort has been invested in seeking to identify the factors that underlie TTR amyloid …

… The generation of descriptive data has formed the basis for inore in-dcpth research on
transthyretin amyloidosis, has resulted in the discovcry of apolipoprotein AI, gelsolin, fibrinogen cx …

… Nonsteroidal anti-inflammatory drugs (NSAIDs) stabilize native TTR tetramers and suppress
TTR amyloid fibril formation [107]. Diflunisal binds to the unoccupied T 4 binding sites in …

… of the molecular mechanisms subserving the development of TTR amyloidosis will provide
… tailored approaches for specific subpopulations of patients suffering from TTR amyloidosis. …

… These amyloid deposits are identified on the basis of their apple-green birefringence under
a … Amyloid deposits are the basis of several conditions that have an enormous social and …

… familial TTR amyloid disease. Tafamidis is the first and currently the only medication approved
to treat TTR familial amyloid polyneuropathy. Here we review the biophysical basis for the …

… knowledge concerning TTR amyloidosis (ATTR amyloidosis) … chaperones, respectively,
on TTR amyloidogenesis in order to … in detail the molecular mechanisms implicated in the …

… of transthyretin would provide a very important basis for hypotheses of the structure of the
amyloid … These findings provide a basis for classifying the transthyretin amyloidoses. The most …