… TTR may also exert harmful effects, as described later. … amyloidosis, focusing on the fine
structures of amyloid fibrils and their impact on neighboring tissues and therapeutic insights from …

… amyloidosis [1, 5]. As the recent development of disease-modifying therapies for ATTR
amyloidosis such as TTR … disease-modifying therapies of ATTR amyloidosis, particularly focusing …

… concerning TTR amyloidosis (ATTR amyloidosis) modulation aiming therapy and discusses
… extracellular chaperones, respectively, on TTR amyloidogenesis in order to contribute for …

… on the TTR gene and protein have provided insight into the pathogenesis of TTR amyloidosis
… The therapeutic strategies for TTR amyloidosis described in this review are summarized in …

… in a subset of TTR amyloid neuropathy patients. Proteomic analysis of this peptide led to
suggest that TTR cleavage happens between TTR tetramer dissociation and deposition into …

… Figure 1 illustrates potential therapy targets within the TTR amyloid fibril pathway. … 2
approved medications for polyneuropathy of hereditary transthyretin amyloidosis (ATTR-PN). The …

… of hereditary and spontaneous types of TTR amyloidosis … therapy for TTR amyloidosis.
Before this, the management of all types of TTR amyloidosis relied on supportive therapy alone (…

… therapies emerge, a complete understanding of the molecular mechanisms subserving the
development of TTR amyloidosis will provide helpful insights … new therapeutic strategies and …

… have human cardiac TTR amyloid deposition that is similar to the lesions seen in people
with wild-type TTR amyloidosis, and the amyloid deposits are made of human TTR monomers. …

… Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressively debilitating, rare
disease associated with high mortality. ATTR-CM occurs when TTR amyloid protein builds up in …