Ultrastructure in transthyretin amyloidosis: from pathophysiology to therapeutic insights
H Koike, M Katsuno - Biomedicines, 2019 - mdpi.com
… TTR may also exert harmful effects, as described later. … amyloidosis, focusing on the fine
structures of amyloid fibrils and their impact on neighboring tissues and therapeutic insights from …
structures of amyloid fibrils and their impact on neighboring tissues and therapeutic insights from …
Transthyretin amyloidosis: update on the clinical spectrum, pathogenesis, and disease-modifying therapies
H Koike, M Katsuno - Neurology and therapy, 2020 - Springer
… amyloidosis [1, 5]. As the recent development of disease-modifying therapies for ATTR
amyloidosis such as TTR … disease-modifying therapies of ATTR amyloidosis, particularly focusing …
amyloidosis such as TTR … disease-modifying therapies of ATTR amyloidosis, particularly focusing …
Modulation of the mechanisms driving transthyretin amyloidosis
F Bezerra, MJ Saraiva, MR Almeida - Frontiers in Molecular …, 2020 - frontiersin.org
… concerning TTR amyloidosis (ATTR amyloidosis) modulation aiming therapy and discusses
… extracellular chaperones, respectively, on TTR amyloidogenesis in order to contribute for …
… extracellular chaperones, respectively, on TTR amyloidogenesis in order to contribute for …
Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses
Y Sekijima, JW Kelly, S Ikeda - Current pharmaceutical design, 2008 - ingentaconnect.com
… on the TTR gene and protein have provided insight into the pathogenesis of TTR amyloidosis
… The therapeutic strategies for TTR amyloidosis described in this review are summarized in …
… The therapeutic strategies for TTR amyloidosis described in this review are summarized in …
Diagnostic and treatment approaches involving transthyretin in amyloidogenic diseases
GY Park, A Jamerlan, KH Shim, SSA An - International journal of …, 2019 - mdpi.com
… in a subset of TTR amyloid neuropathy patients. Proteomic analysis of this peptide led to
suggest that TTR cleavage happens between TTR tetramer dissociation and deposition into …
suggest that TTR cleavage happens between TTR tetramer dissociation and deposition into …
Transthyretin amyloid cardiomyopathy—current and future therapies
JD Yadav, H Othee, KA Chan, DC Man… - Annals of …, 2021 - journals.sagepub.com
… Figure 1 illustrates potential therapy targets within the TTR amyloid fibril pathway. … 2
approved medications for polyneuropathy of hereditary transthyretin amyloidosis (ATTR-PN). The …
approved medications for polyneuropathy of hereditary transthyretin amyloidosis (ATTR-PN). The …
The transthyretin amyloidoses: advances in therapy
S Dubrey, E Ackermann… - Postgraduate Medical …, 2015 - academic.oup.com
… of hereditary and spontaneous types of TTR amyloidosis … therapy for TTR amyloidosis.
Before this, the management of all types of TTR amyloidosis relied on supportive therapy alone (…
Before this, the management of all types of TTR amyloidosis relied on supportive therapy alone (…
A brief journey through protein misfolding in transthyretin amyloidosis (ATTR amyloidosis)
A Gonzalez-Duarte, A Ulloa-Aguirre - International journal of molecular …, 2021 - mdpi.com
… therapies emerge, a complete understanding of the molecular mechanisms subserving the
development of TTR amyloidosis will provide helpful insights … new therapeutic strategies and …
development of TTR amyloidosis will provide helpful insights … new therapeutic strategies and …
Hereditary transthyretin amyloid neuropathies: advances in pathophysiology, biomarkers, and treatment
D Adams, Y Sekijima, I Conceição… - The Lancet …, 2023 - thelancet.com
… have human cardiac TTR amyloid deposition that is similar to the lesions seen in people
with wild-type TTR amyloidosis, and the amyloid deposits are made of human TTR monomers. …
with wild-type TTR amyloidosis, and the amyloid deposits are made of human TTR monomers. …
Treatment of transthyretin amyloid cardiomyopathy: the current options, the future, and the challenges
C Tschöpe, A Elsanhoury - Journal of Clinical Medicine, 2022 - mdpi.com
… Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressively debilitating, rare
disease associated with high mortality. ATTR-CM occurs when TTR amyloid protein builds up in …
disease associated with high mortality. ATTR-CM occurs when TTR amyloid protein builds up in …
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