Neuroinflammation and bloodbrain barrier disruption following traumatic brain injury: pathophysiology and potential therapeutic targets

S Sulhan, KA Lyon, LA Shapiro… - Journal of neuroscience …, 2020 - Wiley Online Library
… This review focuses on the mechanisms involved in traumatic brain injury, separating them
… a traumatic brain injury that intimately interplay with disruption of the bloodbrain barrier. …

[HTML][HTML] Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury

EA van Vliet, XE Ndode-Ekane, LJ Lehto… - Neurobiology of …, 2020 - Elsevier
… -head injury and post-traumatic epilepsy. We also investigated association BBB leakage
with neuroinflammation and epileptogenesis. Finally, we assessed human autopsy brain tissue …

[HTML][HTML] Neuroinflammation in traumatic brain injury: a chronic response to an acute injury

SJ Schimmel, S Acosta, D Lozano - Brain circulation, 2017 - journals.lww.com
… , bloodbrain barrier disruption, and inflammation accompany chronic traumatic brain injury
(TBI) and … One hallmark of both acute and chronic TBI is neuroinflammation. In acute stages, …

The role of neuroinflammation in traumatic brain injury

OI Schmidt, M Infanger, CE Heyde, W Ertel… - … Journal of Trauma, 2004 - Springer
neuroinflammation is further exacerbated by the subsequent intracranial recruitment of blood
mechanism of neuroinflammation contributing to secondary brain damage by complement …

Low cerebral blood flow is a non-invasive biomarker of neuroinflammation after repetitive mild traumatic brain injury

SB Sankar, AF Pybus, A Liew, B Sanders, KJ Shah… - Neurobiology of …, 2019 - Elsevier
… outcome after repetitive mild traumatic brain injury (rmTBI)… cerebral blood flow and underlying
neuroinflammation. Specifically, because neuroinflammation is a driver of secondary injury

[HTML][HTML] Brain–immune interactions and neuroinflammation after traumatic brain injury

V Dinet, KG Petry, J Badaut - Frontiers in neuroscience, 2019 - frontiersin.org
… of the microglia and astrocytes as well as the bloodbrain barrier dysfunction during the
first week after the injury. Considering the neuroinflammatory activity as a causal element of …

Traumatic brain injury, neuroinflammation, and post‐traumatic headaches

CL Mayer, BR Huber, E Peskind - … : The Journal of Head and …, 2013 - Wiley Online Library
… increased blood flow, plasma protein leakage from blood vessels, mast cell degranulation,
and platelet aggregation.119 One stimulus for neuroinflammation may be direct injury to the …

Platelet regulates neuroinflammation and restores bloodbrain barrier integrity in a mouse model of traumatic brain injury

C Gao, H Wang, T Wang, C Luo, Z Wang… - Journal of …, 2020 - Wiley Online Library
… accompanied by microglial activation triggers multiple cell death after traumatic brain injury
(… ‐2 regulates trauma‐induced neuroinflammation and restores bloodbrain barrier integrity. …

Correlations between bloodbrain barrier disruption and neuroinflammation in an experimental model of penetrating ballistic-like brain injury

TL Cunningham, CM Cartagena, XCM Lu… - Journal of …, 2014 - liebertpub.com
Bloodbrain barrier (BBB) disruption is a pathological hallmark of severe traumatic brain
injury (TBI) and is associated with neuroinflammatory events contributing to brain edema and …

[HTML][HTML] Single mild traumatic brain injury induces persistent disruption of the blood-brain barrier, neuroinflammation and cognitive decline in hypertensive rats

N Szarka, L Toth, A Czigler, Z Kellermayer… - International Journal of …, 2019 - mdpi.com
… of bloodblood pressure. Therefore, future studies should test whether treated hypertension
exacerbates the effect of mild traumatic brain injury on BBB disruption, neuroinflammation