Recognizing and overcoming resistance to new beta-lactam/beta-lactamase inhibitor combinations

S Ho, L Nguyen, T Trinh, C MacDougall - Current infectious disease …, 2019 - Springer
… therapy for treatment of CRE infected patients across all infections [54]. Currently, TANGO
III is in recruitment phase, comparing meropenem-vaborbactam to piperacillin-tazobactam for …

Community infections caused by extended-spectrum β-lactamase–producing Escherichia coli

…, JP Horcajada, T Tórtola, B Mirelis… - Archives of internal …, 2008 - jamanetwork.com
infections due to extended-spectrum β-lactamase-producing organisms. … treatment of
extended spectrum beta-lactamase-producing Escherichia coli-related lower urinary tract infections

Treatment options for extended-spectrum beta-lactamase (ESBL) and AmpC-producing bacteria

RG D'Angelo, JK Johnson, JT Bork… - Expert opinion on …, 2016 - Taylor & Francis
… In the treatment of infections caused by AmpC-producing Enterobacteriaceae, FEP has
been shown to be a clinically useful carbapenem-sparing alternative. Carbapenems and FEP …

Infectious Diseases Society of America guidance on the treatment of extended-spectrum β-lactamase producing Enterobacterales (ESBL-E), carbapenem-resistant …

PD Tamma, SL Aitken, RA Bonomo… - Clinical Infectious …, 2021 - academic.oup.com
… guidance documents for the treatment of specific infectious processes. Guidance documents
address specific clinical questions for difficult-to-manage infections that are not covered by …

Betalactams

L Balsalobre, A Blanco, T Alarcón - Antibiotic drug resistance, 2019 - Wiley Online Library
… Due to lack of new antibiotics to treat infections produced by multiresistant bacteria, the
InfectiousBetalactamases producing bacteria, especially carpabenemases, are responsible for …

Bloodstream Infections Due to Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae: Risk Factors for Mortality and Treatment …

CI Kang, SH Kim, WB Park, KD Lee… - Antimicrobial agents …, 2004 - Am Soc Microbiol
… the treatment of infections caused … treatment outcomes of bloodstream infections due to
ESBL-producing organisms. We aimed to evaluate treatment outcomes of bloodstream infections

Beta-lactamases in Enterobacteriaceae infections in children

CA Moxon, S Paulus - Journal of infection, 2016 - Elsevier
… cephalosporins or beta-lactam/beta-lactamase inhibitors combination to treat those infections,
… not advocate the use of beta-lactam/beta-lactamase inhibitors combination to treat ESBL …

Management of infections caused by extended-spectrum βlactamase-producing Enterobacteriaceae: current evidence and future prospects

CC Sheu, SY Lin, YT Chang, CY Lee… - Expert Review of Anti …, 2018 - Taylor & Francis
… intra-abdominal infections. The introduction of these new β-lactam/β-lactamase inhibitor
combinations offers new carbapenem-sparing options for the treatment of ESBL infections. …

Old and new beta-lactamase inhibitors: Molecular structure, mechanism of action, and clinical Use

D Carcione, C Siracusa, A Sulejmani, V Leoni, J Intra - Antibiotics, 2021 - mdpi.com
… Carbapenems can usually be used to treat infections due to AmpC-producing bacteria, but
carbapenem resistance has been reported in some organisms, since mutations can reduce …

β-lactam/β-lactamase inhibitor combinations: from then to now

KA Toussaint, JC Gallagher - Annals of Pharmacotherapy, 2015 - journals.sagepub.com
… β-Lactam antibiotics are a mainstay for the treatment of many infections. The addition of β-lactamase
inhibitors enhances their activity against organisms that produce β-lactamases; …