… for the development of anti-cytokine therapeutic strategies in sepsis, such as inhibitors of
TNFα… cytokine inhibitors may be beneficial in infectious models of sepsis treated with antibiotics. …

… sepsis and processes underpinning its development if we are either to optimize these present
clinical therapies or … of the apoptotic process represent potential novel therapeutic targets. …

… The failure of many therapies in sepsis is likely related to the … of immune-adjuvant therapies
in sepsis must be based on … with severe sepsis or septic shock were treated with GM-CSF …

… sepsis. Here we focus on studies developing TLR agonists and antagonists for the treatment
of infectious diseases and sepsis. … targets for developing anti-sepsis drugs, and antagonistic …

… rational use of antibiotics in sepsis and presents evidence-based recommendations for optimal
antibiotic therapy… the pathogens recently exposed to therapeutic antibiotic concentrations. …

… Based on this, it was proposed that the application of vitamin E in septic neonates might
not be rational. Even more, one Cochrane study documented that prophylactic vitamin E …

… challenges in the diagnosis, treatment, and management of patients with sepsis. Here, we
… , rational employment of antibiotics, evaluation of the affection of interventions, therapeutic …

… evolution of sepsis therapy (Table 1) and identifies possible causes for why rational therapies
failed in human trials. In addition, this article examines potential future sepsis targets and …

… with sepsis and septic shock. This article reviews sepsis pathophysiology and the rational use
of … to hold an important place in the therapeutic armamentarium of sepsis and septic shock …

… antimicrobial therapy is critical in early achievement of therapeutic drug … in septic shock, a
rational approach may be to incorporate combination therapy in the opening salvo of treatment …