… Drug resistance amplification was defined as an increase in the number of drugs towards
which MTB was resistant … To calculate the drug resistance amplification and exogenous re-…

… multidrug-resistant tuberculosis (MDRTB). We present a new mathematical model (the
amplifier … -MDR) strains of drug-resistant Mycobacterium tuberculosis. We reconstruct possible …

… Previous data on drug resistance among previously treated patients with TB in Uganda are
… associated with drug resistance among treatment-experienced patients with TB in Kampala, …

… Drug resistance amplification and transmission We observed higher proportions of drug
resistance amplification for INH compared to RIF for both the high DR-TB incidence settings we …

… In conclusion, our study demonstrated a high risk of amplification of drug resistance among
patients treated using standard DOTS regimens. These results indicate that, in areas with …

… control drug-susceptible (DS) and multi-drug resistant (MDR) TB. In this study, we developed
a two strain TB mathematical model with amplification and fit it to the Bangladesh TB data …

… stewardship, and concern about the rapid amplification of drug resistance rendering
these newer agents useless over time. Clinical trials informing this issue are eagerly awaited. …

… diagnosis of TB and anti-tuberculous drug resistance in clinical microbiology laboratories. …
complex and simultaneously detect genetic mutations related to drug resistance. Amplified …

… drug resistance-genotyping workflow for M. tuberculosis, harnessing targeted isothermal
amplification … We developed targeted isothermal amplification assays for three MDR-associated …

… 10 million individuals fell ill with tuberculosis (TB) and 3 million of … drug-resistant TB. Of
the estimated 465 000 patients with rifampicin-resistant and multi-drug resistant TB (RR/MDR-TB)…