Colitis-targeted hybrid nanoparticles-in-microparticles system for the treatment of ulcerative colitis

M Naeem, J Lee, MA Oshi, J Cao, SP Hlaing, E Im… - Acta Biomaterialia, 2020 - Elsevier
Nanoparticle (NP)-based drug delivery systems accumulate in the disrupted epithelium of
inflamed colon tissue in ulcerative colitis. … an advanced colitis-targeted hybrid nanoparticles-in-…

Oral delivery of superoxide dismutase by lipid polymer hybrid nanoparticles for the treatment of ulcerative colitis

Y Cui, T Zhu, X Zhang, J Chen, F Sun, Y Li… - Chinese Chemical …, 2022 - Elsevier
hybrid nanoparticles (R8-PEG-PPNPs) that deliver superoxide dismutase (SOD) for the
treatment of ulcerative colitis (… The nanoparticles (NPs) are uniformly dispersed with a complete …

[HTML][HTML] Combination therapy for ulcerative colitis: orally targeted nanoparticles prevent mucosal damage and relieve inflammation

B Xiao, Z Zhang, E Viennois, Y Kang, M Zhang… - Theranostics, 2016 - ncbi.nlm.nih.gov
therapy is an emerging strategy that is under intensive preclinical investigation for the treatment
… cells and macrophages in the colon tissue with ulcerative colitis (UC), which is usually …

Antioxidant enzymes sequestered within lipid–polymer hybrid nanoparticles for the local treatment of inflammatory bowel disease

Z Le, Z He, H Liu, L Liu, Z Liu… - ACS Applied Materials & …, 2021 - ACS Publications
… Inflammatory bowel disease (IBD), which includes two main forms of ulcerative colitis (UC)
and Crohn’s disease, has been a major threat to public health around the world. (1) In addition…

[HTML][HTML] Cupriavidus necator-Produced Polyhydroxybutyrate/Eudragit FS Hybrid Nanoparticles Mitigates Ulcerative Colitis via Colon-Targeted Delivery of …

J Lee, A Saparbayeva, SP Hlaing, D Kwak, H Kim… - Pharmaceutics, 2022 - mdpi.com
… Due to enhanced CSA delivery to colitis tissues, CSA-PENPs exhibited potent … colitis model.
Overall, CSA-PENPs could be a promising drug-delivery system for treating ulcerative colitis. …

[HTML][HTML] Hydrogel–metal-organic-framework hybrids mediated efficient oral delivery of siRNA for the treatment of ulcerative colitis

M Gao, C Yang, C Wu, Y Chen, H Zhuang… - Journal of …, 2022 - Springer
… They are suitable for the delivery of high siRNA dosage to treat ulcerative colitis. However, …
-organic framework hybrid delivery system. siRNA loaded MOF nanoparticles encapsulated in …

Nanoparticles as budding trends in colon drug delivery for the management of ulcerative colitis

A Singh, K Kaur, UK Mandal… - … : Recent Patents on …, 2020 - ingentaconnect.com
treatment with dendrimer related polymeric nanoparticles for the delivery of nucleic acids to
… molecules/antigens to a subject to prevention or treatment of diseases like Ulcerative colitis. …

Enteric-coated gelatin nanoparticles mediated oral delivery of 5-aminosalicylic acid alleviates severity of DSS-induced ulcerative colitis

A Ahmad, MM Ansari, RK Mishra, A Kumar… - Materials Science and …, 2021 - Elsevier
… drugs, nanotechnology based … for treatment of ulcerative colitis and other intestinal disorders
[33]. Therefore, this study was designed to prepare 5-ASA loaded gelatin nanoparticles and …

Leveraging thiol-functionalized biomucoadhesive hybrid nanoliposome for local therapy of ulcerative colitis

A Ahmad, A Kumar, RK Mishra, N Ali, U Navik… - Biomaterials, 2025 - Elsevier
… Directly administering medication to inflamed intestinal sites for treating ulcerative colitis (UC…
in therapy to treat colitis aim to improve local drug availability that is enema therapy at the …

Hyaluronic acid-functionalized DDAB/PLGA nanoparticles for improved oral delivery of magnolol in the treatment of ulcerative colitis

W Li, J Lin, J Zhou, S He, A Wang, Y Hu, H Li… - International Journal of …, 2024 - Elsevier
… are major challenges in the treatment of ulcerative colitis (UC). … and preparation of a
hybrid nanoparticle system (LPNs) … positively charged lipid-polymer hybrid nanoparticles (HA-LPNs…