… in treatment protocols. The mechanisms involved in anti-TNF-α therapy for the treatment of
… This review underlines the major impact the discovery of TNF-α has had on the treatment of …

… disease, and anti-TNF-α therapy with infliximab is effective … the usual dosage [89] – a finding
that may offer clues to the … AS, were treated with infliximab with a dose regimen similar to …

… of treatment-limiting adverse responses of TNFα antagonists. It is … In resonance with this
finding, another study showed that the … no effect at the dose regimen used on decreasing the gut …

… candidate biomarkers to predict therapeutic outcomes of anti-TNFα treatment regimes. … to
anti-TNFα therapy within the first days of treatment. The objective of our approach is to discover …

… also continued with their previous regimens. Etanercept … finding of the 24-week STAR
study was that use of a TNF-… In most circumstances, the treatment regimen for adults with …

… DISCOVER-1), conducted to assess guselkumab in patients with active psoriatic arthritis,
including those who were previously treated with one or two TNF … dosing regimens also elicited …

… manner 83 ; consistent with this finding, data published in 2015 … and magnitude depending
on the treatment regimen. … medication and differences in dosing regimens. More importantly, …

… for treating patients initially with aggressive regimens to quickly … and asthma, anti-TNFα
agents appear to more profoundly … studies in early 1990s discovered a major role of TNFα in the …

… Despite the discovery of TNFα bioactivity in the 1970s by Old andcolleagues (10,11) and its
… regimes. Zero change in the radiographicscore from baseline in about 50% of the infliximab …

… The response rates to these regimens are better when the patients are treated with the …
-TNF antibody fragment for the treatment of Crohn’s disease. In a placebo-controlled dose-finding …