… treatment strategies and challenges. We review new technological advances in mycobacteriology,
their impact on TB drug discovery and development, … the development of curative drug …

… treatment with the drug ameliorated the development of hypotension in rats that were
challenged with either LPS or purified LTA 96 . Interestingly, in these studies, pretreatment and post…

… with drug development and treatment … treatment consists of an initial 2-month phase of
treatment with INH, RIF, PZA, and ethambutol (EMB) followed by a continuation phase of treatment …

… drugs. Over the next several decades, drug development should focus on agents for
treatment-experienced patients that are as safe and convenient as agents meant for treatment-naive …

… that illustrate the importance of a rational approach to drug development. We will discuss
strategies … is essential to identifying the mechanism of resistance and a new treatment strategy. …

… and the advent of recombinant-screening strategies, drugs tended to be less specific in their
… targets, resulting in drugs perhaps more suitable for the treatment of heterogeneous and …

… STRATEGY FOR CLINICAL DEVELOPMENT This section recommends strategies for continued
development of the drug… includes the strategy for the clinical phase of development. The …

… strategies, … drug development that will help accelerate approval of drugs, and aim to provide
more-effective treatments alongside companion diagnostic tests to ensure the right treatment …

… Attention was focussed primarily on the use of human hepatocytes in the drug development
setting, rather than the use of ligand binding assays and reporter gene methods which were …

… time for the development of truly novel approaches to drug development and treatment of …
As these drugs will not represent significant advances in the treatment of schizophrenia, this …