… treatment strategies and challenges. We review new technological advances in mycobacteriology,
their impact on TB drug discovery and development, … the development of curative drug …

… treatment with the drug ameliorated the development of hypotension in rats that were
challenged with either LPS or purified LTA 96 . Interestingly, in these studies, pretreatment and post…

… that illustrate the importance of a rational approach to drug development. We will discuss
strategies … is essential to identifying the mechanism of resistance and a new treatment strategy. …

… with drug development and treatment … treatment consists of an initial 2-month phase of
treatment with INH, RIF, PZA, and ethambutol (EMB) followed by a continuation phase of treatment …

… assessment of development potential; setting up a rational in vivo drug-drug interaction …
to drug interactions and may help to improve the quality of drug treatment and to save costs. …

… strategies, … drug development that will help accelerate approval of drugs, and aim to provide
more-effective treatments alongside companion diagnostic tests to ensure the right treatment …

… In the specific context of drug development, the US Food and Drug Administration (FDA)
will accept qualification of a biomarker in several specific contexts, including stratification of …

… Thus, we should view drug development as a model building … to inform our decision-making
and drug development strategy. … The treatment effect (Δ) of a drug relative to placebo or an …

… treatment of biofilm infections presents a considerable unmet clinical need. To date, there
are no drugs … , several approaches are in early-stage development. Here, we review current …

… , treatment, monitoring, and patient support. Incentives for drug development provided by …
drugs. Although there may still be challenges ahead for the pharmaceutical industry, orphan …