Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer
… during EGFR-TKI treatment (250 mg daily gefitinib or 150 mg daily erlotinib) between April
… Two of the 15 patients received gefitinib and erlotinib treatment; therefore, we analyzed 17 …
… Two of the 15 patients received gefitinib and erlotinib treatment; therefore, we analyzed 17 …
Antitumor activity of erlotinib (OSI-774, Tarceva) alone or in combination in human non-small cell lung cancer tumor xenograft models
B Higgins, K Kolinsky, M Smith, G Beck… - Anti-cancer …, 2004 - journals.lww.com
… kinase inhibitor erlotinib in athymic nude mice bearing non-small cell lung cancer (NSCLC) …
At the end of this study (day 47 post-tumor implantation, treatment day 19), erlotinib 100 mg/…
At the end of this study (day 47 post-tumor implantation, treatment day 19), erlotinib 100 mg/…
Clinical pharmacokinetics of erlotinib in patients with solid tumors and exposure‐safety relationship in patients with non–small cell lung cancer
JF Lu, SM Eppler, J Wolf, M Hamilton… - Clinical …, 2006 - Wiley Online Library
… Erlotinib is indicated for the treatment of patients with locally advanced or metastatic non-small
cell lung cancer (… for treatment of locally advanced, inoperable, or metastatic pancreatic …
cell lung cancer (… for treatment of locally advanced, inoperable, or metastatic pancreatic …
… and in KRAS are predictive and prognostic indicators in patients with non–small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
DA Eberhard, BE Johnson, LC Amler… - Journal of clinical …, 2005 - ascopubs.org
… ) mutations have been associated with tumor response to treatment with single-agent EGFR
… small-cell lung cancer (NSCLC). The implications of EGFR mutations in patients treated with …
… small-cell lung cancer (NSCLC). The implications of EGFR mutations in patients treated with …
Treatment of non–small-cell lung cancer with erlotinib or gefitinib
VD Cataldo, DL Gibbons, R Pérez-Soler… - … England Journal of …, 2011 - Mass Medical Soc
… Approximately 85 to 90% of all cases of lung cancer are non–small-cell lung cancer (NSCLC).
Advanced-stage NSCLC is currently considered an incurable disease for which standard …
Advanced-stage NSCLC is currently considered an incurable disease for which standard …
TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non–small-cell lung cancer
RS Herbst, D Prager, R Hermann… - Journal of clinical …, 2005 - ascopubs.org
… Median survival for patients treated with erlotinib was 10.6 v 10.5 months for placebo (hazard
ratio, 0.99; 95% CI, 0.86 to 1.16; P = .95). There was no difference in OR or median TTP. …
ratio, 0.99; 95% CI, 0.86 to 1.16; P = .95). There was no difference in OR or median TTP. …
A Prospective Evaluation of Circulating Tumor Cells and Cell-Free DNA in EGFR-Mutant Non–Small Cell Lung Cancer Patients Treated with Erlotinib on a Phase II …
M Yanagita, AJ Redig, CP Paweletz, SE Dahlberg… - Clinical Cancer …, 2016 - AACR
… Tumor genotyping has emerged as the standard of care for patients with newly diagnosed
non–small cell lung cancer (NSCLC) because of the efficacy of targeted therapies for patients …
non–small cell lung cancer (NSCLC) because of the efficacy of targeted therapies for patients …
Effects of Erlotinib in EGFR Mutated Non-Small Cell Lung Cancers with Resistance to Gefitinib
DB Costa, KSH Nguyen, BC Cho, LV Sequist… - Clinical cancer …, 2008 - AACR
… , we cannot excluded the possibility that T790M was acquired while on erlotinib therapy. …
survival in non-small cell lung cancer patients treated with gefitinib or erlotinib. Clin Cancer Res …
survival in non-small cell lung cancer patients treated with gefitinib or erlotinib. Clin Cancer Res …
[HTML][HTML] … III study of erlotinib versus chemotherapy as first-line treatment of EGFR mutation-positive advanced non-small-cell lung cancer (OPTIMAL, CTONG-0802)
C Zhou, YL Wu, G Chen, J Feng, XQ Liu, C Wang… - Annals of …, 2015 - Elsevier
… treatments may confound the true effect of first-line treatment on OS. In the current study, ∼40%
of erlotinib-treated … did not receive any post-study treatment. On the other hand, almost 80…
of erlotinib-treated … did not receive any post-study treatment. On the other hand, almost 80…
Non–Small Cell Lung Cancer Treated with Erlotinib: Heterogeneity of 18F-FDG Uptake at PET—Association with Treatment Response and Prognosis
GJR Cook, ME O'Brien, M Siddique, S Chicklore… - Radiology, 2015 - pubs.rsna.org
… after commencing treatment with erlotinib. First-order and high-order primary tumor texture
features reflecting image heterogeneity, standardized uptake values, metabolic tumor volume, …
features reflecting image heterogeneity, standardized uptake values, metabolic tumor volume, …