… However, gefitinib did not result in the appearance of drug-induced liver injury in our patient…
been similar reports regarding erlotinib treatment following gefitinib-induced liver injury [9, 10…

… liver injury (DILI) refers to the liver injury caused by the toxicity of the drug itself or its metabolites
during the clinical drug treatment, … liver injury, and DILI is the main cause of acute liver …

… liver injury. First, we administered GEF at a dose that is insufficient to induce liver injury in
mice … We further evaluated the possible mechanism of liver injury by hepatic mRNA expression …

… liver injury induced by gefitinib is g enerally mild and self-limiting without necessitating dose
reduction or discontinuation of treatment… to detect moderate to severe liver injury. Whether g …

… gefitinib therapy and the liver function recovered to normal after 2 months 16 . In our study,
patients developed liver injury … severe liver injury tends to present in the early stage of gefitinib …

… a liver biopsy specimen revealed drug-induced liver injury, and a drug lymphocyte stimulation
test yielded a positive result for gefitinib, … Gefitinib therapy was therefore discontinued. The …

… patient developed grade 4 liver injury during the initial gefitinib treatment. Four sequential …
following withdrawal of gefitinib, and the subsequent gefitinib rechallenge, combined with liver-…

… changes of TBL and ALP suggested hepatocellular injury. Unfortunately we could not perform
biopsy of the liver and it was impossible to investigate the nature of liver injury any further. …

… , liver dysfunction and acute lung injury. Five of the 12 patients who were considered to have
suffered acute lung injury … before use of gefitinib, five developed acute lung injury during the …

… of liver damage and previous chemotherapy (P = 0.009). The objective response rates of
patients treated with daily gefitinib 250 mg and alternate-day gefitinib following liver damage …