Triazine dendrimers as drug delivery systems: From synthesis to therapy

J Lim, EE Simanek - Advanced drug delivery reviews, 2012 - Elsevier
Triazine dendrimers have been used to deliver genes as … The delivery of siRNA with the
flexible G2 triazine dendrimers … flexible dendrimers were employed for further study in siRNA

Molecular modeling and in vivo imaging can identify successful flexible triazine dendrimer-based siRNA delivery systems

OM Merkel, M Zheng, MA Mintzer, GM Pavan… - Journal of controlled …, 2011 - Elsevier
… suitable siRNA delivery systems based on flexible generation 2–4 triazine dendrimers by …
The siRNA binding properties of the dendrimers and PEI 25 kDa were simulated, binding …

[HTML][HTML] Dendrimers for siRNA delivery

S Biswas, VP Torchilin - Pharmaceuticals, 2013 - mdpi.com
… effective gene delivery vector delivered significant amount of siRNA [102,104]. A … triazine
dendrimer for siRNA delivery. In comparison with PEI, 25 KDa, flexible G2-4 triazine dendrimers

Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: the effects of peripheral groups and core structure on biological activity

OM Merkel, MA Mintzer, D Librizzi… - Molecular …, 2010 - ACS Publications
… (28) In continuation we aim to elucidate structure−activity relationships regarding the impact
of peripheral and core functionality of triazine dendrimers on complex formation with siRNA

Dendrimers as non-viral vectors for siRNA delivery

X Liu, P Rocchi, L Peng - New Journal of Chemistry, 2012 - pubs.rsc.org
… current status of dendrimers as siRNA delivery vectors, focusing on the different … of various
dendrimer vectors investigated for their siRNA delivery capacity. … Recently, a series of triazine

Triazine dendrimers for DNA and siRNA delivery: Progress, challenges, and opportunities

MA Mintzer, OM Merkel, T Kissel… - Dendrimer‐Based Drug …, 2012 - Wiley Online Library
… our triazine dendrimers as vectors for DNA and siRNA transfection, we looked to other
groups to determine what structural variations they had found most suitable for gene delivery in …

Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity

OM Merkel, MA Mintzer, J Sitterberg… - Bioconjugate …, 2009 - ACS Publications
… The potential of triazine dendrimers as gene delivery systems … These dendrimers may be
attractive candidates, as they can be … In addition, triazine dendrimers show low toxicity, both in …

[PDF][PDF] MOLECULAR MODELING AND IN VIVO IMAGING CAN IDENTIFY SUCCESSFUL HYPERFLEXIBLE TRIAZINE DENDRIMER-BASED SIRNA DELIVERY …

OM Merkel, M Zheng, MA Mintzer, GM Pavan… - … and siRNA DELIVERY, 2012 - core.ac.uk
… suitable siRNA delivery systems based on hyperflexible generation 2-4 triazine dendrimers
by … The siRNA binding properties of the dendrimers in comparison to PEI 25 kDa were …

[HTML][HTML] Two decades of triazine dendrimers

EE Simanek - Molecules, 2021 - mdpi.com
… We concluded that triazine dendrimers offer a promising platform for drug delivery with a
high degree of control that can be exercised over composition. However, targeting that relied …

Dendrimers as carriers for siRNA delivery and gene silencing: a review

J Wu, W Huang, Z He - The Scientific World Journal, 2013 - Wiley Online Library
delivery systems. In this review, the development of dendrimer-based siRNA delivery
2011, Merkel et al. tried to develop siRNA delivery carriers based on flexible G2–G4 triazine