TRIM32 ubiquitin E3 ligase, one enzyme for several pathologies: From muscular dystrophy to tumours

E Lazzari, G Meroni - The international journal of biochemistry & cell …, 2016 - Elsevier
TRIM32 ubiquitin E3 ligase activity is necessary for … of view, TRIM32 was reported to be
an E3 ubiquitin ligase able to … the role of TRIM32 in mediating target proteins proteasomal …

TRIM32 protein sensitizes cells to tumor necrosis factor (TNFα)-induced apoptosis via its RING domain-dependent E3 ligase activity against X-linked inhibitor of …

YS Ryu, Y Lee, KW Lee, CY Hwang, JS Maeng… - Journal of Biological …, 2011 - ASBMB
TRIM32 has specific E3 ligase activity against XIAP and further investigate the role of TRIM32
in … We demonstrate that TRIM32 interacts directly with and down-regulates XIAP through its …

TRIM32 is an E3 ubiquitin ligase for dysbindin

M Locke, CL Tinsley, MA Benson… - Human molecular …, 2009 - academic.oup.com
… role of TRIM32 in muscle demonstrated that TRIM32 binds to … that TRIM32–D487N behaved
like the wild-type protein with … ligase activity towards dysbindin, we tested whether these …

E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

J Liu, C Zhang, XL Wang, P Ly, V Belyi… - Cell Death & …, 2014 - nature.com
… role of TRIM32 in tumorigenesis. TRIM32 was reported to possess E3 Ub ligase activity, …
(a) Ectopic expression of TRIM32 negatively regulated the exogenous p53 protein in p53-…

Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity

MG Koliopoulos, D Esposito, E Christodoulou… - The EMBO …, 2016 - embopress.org
… TRIM ligases TRIM25 and TRIM32 and show how their oligomeric state is linked to catalytic
activity. … TRIM proteins are oligomeric E3 ligases that require RING dimerization for catalytic …

RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties

EJ Horn, A Albor, Y Liu, S El-Hizawi… - …, 2004 - academic.oup.com
… We propose a model in which Trim32 activities as an E3-ubiquitin ligase favor initiated
cell survival in carcinogenesis by blocking UVB-induced TNFα apoptotic signaling. …

SUMO E3 ligase activity of TRIM proteins

Y Chu, X Yang - Oncogene, 2011 - nature.com
… To determine whether SUMO E3 activity is a shared feature of TRIM proteins, we screened
… few TRIM family proteins—including TRIM27 and TRIM32—exhibited much higher activity in …

Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component

E Kudryashova, J Wu, LA Havton… - Human molecular …, 2009 - academic.oup.com
… in WT skeletal muscles to the TRIM32 protein based upon the … TRIM2 and TRIM32 have
confirmed E3 ubiquitin ligase activity (… TRIM32 E3 ubiquitin ligase activity, the most potent E2 for …

Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin

E Kudryashova, D Kudryashov, I Kramerova… - Journal of molecular …, 2005 - Elsevier
… observed Trim32 protein expression … ligase activity of Trim32. In the presence of UbcH6,
ATP, ubiquitin, and E1, full-length Trim32 formed ubiquitin conjugates, whereas ΔRING Trim32

Ubiquitin ligase TRIM32 promotes dendrite arborization by mediating degradation of the epigenetic factor CDYL

L Liu, TT Liu, GG Xie, XQ Zhu, Y Wang - The FASEB Journal, 2022 - Wiley Online Library
… protein 32 (TRIM32), which has E3 ligase activity, is critically involved in dendritic arborization
by regulating CDYL. TRIM32 belongs to a member of the TRIM- NHL protein family. The N…