… evolution of neurotrophins and of Trk receptors during evolution … neurotrophins and Trk
receptors. In fish, additional duplications have generated larger numbers of neurotrophin and Trk …

… These results strongly implicate Trk as the central effector of NGF actions. The previously
identified NGF receptor, p75NGFR, has a role as an accessory protein that modifies the ligand-…

… The action of CGS 21680 required TrkA receptors, because K252a (100 nM) eliminated
the positive effects of CGS 21680 under similar conditions that blocked the activation of …

… receptors in the ontogeny of the mammlian nervous system. For instance, mice deficient for
Trk receptors … Mice lacking TrkB tyrosine kinase receptors die postnatally due to their inability …

… capturing and presenting neurotrophins to neuronsexpressing full-length Trk receptors. When
… intermediates activated by Trk receptor action. It isunclear how the activation state of these …

… , neurotrophins and their cognate Trk receptors fit well with the neurotrophic hypothesis, as
… exhibit a predominant dependence on a specific neurotrophin during the period of naturally …

… of neurotrophins on sensory neurons are now evident, including paracrine and autocrine
actions … properties of the neurotrophin family, their receptors and their actions and specificity for …

… Although neurotrophin receptors are not normally expressed on fibroblasts, there is growing
evidence for naturally occurring targets of neurotrophin action in which the Trk receptors do …

… The actions of neurotrophins are dictated by two classes of cell surface receptors, the Trk
receptor … to account for adenosine’s neurotrophic effects is through the action of Trk receptors. …

… (referred to as trk or trkA) receptor tyrosine kinase. The related trkB receptor tyrosine kinase
binds … We focus here on recent progress in defining 1) neurotrophin protein structure; 2) the …