Capsaicin receptor: TRPV1 a promiscuous TRP channel

SC Pingle, JA Matta, GP Ahern - … Receptor Potential (TRP) Channels, 2007 - Springer
… The receptor has a diverse tissue distribution, with high … channel with significant permeability
to calcium, protons, and large polyvalent cations. It is the most polymodal TRP channel, …

Capsaicin, transient receptor potential (TRP) protein subfamilies and the particular relationship between capsaicin receptors and small primary sensory neurons

H Nakagawa, A Hiura - Anatomical science international, 2006 - Wiley Online Library
… concerning capsaicin receptors is discussed. The terms ‘VR1’ or ‘TRPV1’ have been used
interchangeably throughout the present review as the name for the capsaicin receptor on the …

Capsaicin receptor in the pain pathway

M Tominaga, D Julius - The Japanese Journal of Pharmacology, 2000 - jstage.jst.go.jp
… The cloned capsaicin receptor (VR1) is a nonselective cation channel with six … of the TRP
(transient receptor potential) channel family. VR1 is activated not only by capsaicin but also by …

The capsaicin receptor: a heat-activated ion channel in the pain pathway

MJ Caterina, MA Schumacher, M Tominaga, TA Rosen… - Nature, 1997 - nature.com
… This receptor is a non-selective cation channel that is structurally related to members of the
TRP family of ion channels. The cloned capsaicin receptor is also activated by increases in …

Spider toxins activate the capsaicin receptor to produce inflammatory pain

J Siemens, S Zhou, R Piskorowski, T Nikai… - Nature, 2006 - nature.com
… Our findings show that TRP channels can now be included as molecular targets of ICK
toxins, or, for that matter, any peptide toxin. With the exception of two scorpion ICK peptides that …

The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology

I Nagy, P Sántha, G Jancsó, L Urbán - European journal of pharmacology, 2004 - Elsevier
capsaicin receptor is particularly interesting as native TRPV1 might form heteromers with other
TRP channels … our previous finding that native capsaicin receptors expressed by cultured …

[HTML][HTML] Understand spiciness: mechanism of TRPV1 channel activation by capsaicin

F Yang, J Zheng - Protein & cell, 2017 - Springer
… Though the capsaicin receptor is known to function as TRPV1 homotetramer, different
subunits within the TRP family are able to form heteromeric channels (Cheng et al., 2007, 2010; …

[HTML][HTML] TRP channels and pain

DN Cortright, JE Krause, DC Broom - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
… of the capsaicin receptor, now known as TRPV1, transient receptor potential (TRP) channels
… Several TRP channels exhibit sensitivity to substances previously known to cause pain or …

Nociception and TRP channels

M Numazaki, M Tominaga - Current Drug Targets-CNS & …, 2004 - ingentaconnect.com
… of both capsaicin and its ultra potent analogue, resiniferatoxin. From its deduced amino acid
… , capsaicin receptor is predicted to function as an ion channel. The capsaicin receptor VR1 …

TRP channels and pain

DN Cortright, A Szallasi - Current pharmaceutical design, 2009 - ingentaconnect.com
… Differential expression of the capsaicin receptor TRPV1 and related novel receptors
TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic …