Gene expression in Trypanosoma brucei: lessons from high-throughput RNA sequencing

…, K Gunasekera, GAM Cross, T Ochsenreiter - Trends in …, 2011 - cell.com
Trypanosoma brucei undergoes major biochemical and … published high-throughput RNA
sequencing studies in light of the … and give insights into the regulation of gene expression in T. …

RNA-Seq analysis validates the use of culture-derived Trypanosoma brucei and provides new markers for mammalian and insect life-cycle stages

A Naguleswaran, N Doiron, I Roditi - BMC genomics, 2018 - Springer
Background Trypanosoma brucei brucei, the parasite causing Nagana in domestic animals,
is closely related to the parasites causing sleeping sickness, but does not infect humans. In …

RNA-seq analysis of small RNPs in Trypanosoma brucei reveals a rich repertoire of non-coding RNAs

S Michaeli, T Doniger, SK Gupta, O Wurtzel… - Nucleic Acids …, 2012 - academic.oup.com
… the power of deep sequencing of RNA (RNA-seq) to examine the … ) of Trypanosoma brucei,
an important protozoan parasite. We identified new C/D and H/ACA small nucleolar RNAs (…

Single-cell RNA sequencing of Trypanosoma brucei from tsetse salivary glands unveils metacyclogenesis and identifies potential transmission blocking antigens

A Vigneron, MB O'Neill, BL Weiss… - Proceedings of the …, 2020 - National Acad Sciences
… , we performed single-cell RNA sequencing (scRNA-seq) from a pool of 2,045 … RNA
sequencing (scRNA-seq) to profile the transcriptomic landscape from a pool of 2,045 individual T

RNA-seq de novo Assembly Reveals Differential Gene Expression in Glossina palpalis gambiensis Infected with Trypanosoma brucei gambiense vs. Non-Infected …

I Hamidou Soumana, C Klopp, S Ravel… - Frontiers in …, 2015 - frontiersin.org
Trypanosoma brucei gambiense (Tbg), causing the sleeping sickness chronic form,
completes its developmental cycle within the tsetse fly vector Glossina palpalis gambiensis (Gpg) …

The establishment of variant surface glycoprotein monoallelic expression revealed by single-cell RNA-seq of Trypanosoma brucei in the tsetse fly salivary glands

S Hutchinson, S Foulon, A Crouzols, R Menafra… - PLoS …, 2021 - journals.plos.org
… The long and complex Trypanosoma bruceiRNA-sequencing (scRNA-seq) on these
trypanosome populations. We were able to capture the developmental program of trypanosomes in …

The Transcriptome of the Human Pathogen Trypanosoma brucei at Single-Nucleotide Resolution

NG Kolev, JB Franklin, S Carmi, H Shi… - PLoS …, 2010 - journals.plos.org
… , and the publication in 2005 of the genome sequence provided the first glance at the coding
… We used next generation RNA sequencing (RNA-Seq) to map transcribed regions and RNA

Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing

EM Briggs, F Rojas, R McCulloch, KR Matthews… - Nature …, 2021 - nature.com
… Single-cell RNA sequencing (scRNA-seq) offers the opportunity to address this knowledge …
Recently, scRNA-seq has been used to study antigenic variation in T. brucei 32 , as well as to …

Transcriptome Profiling of Trypanosoma brucei Development in the Tsetse Fly Vector Glossina morsitans

AF Savage, NG Kolev, JB Franklin, A Vigneron… - PLoS one, 2016 - journals.plos.org
… Here, we used high-throughput RNA-Sequencing (RNA-Seq) to profile Trypanosoma brucei
… (mVSGs) and the surface coat protein brucei alanine rich protein or BARP were extremely up…

The Cell Cycle Regulated Transcriptome of Trypanosoma brucei

SK Archer, D Inchaustegui, R Queiroz, C Clayton - PloS one, 2011 - journals.plos.org
… of a flagellar protein regulon with a highly conserved sequence motif, bearing similarity to
consensus PUF-protein binding motifs. RNA sequence motifs that are functional in cell-cycle …