… vivo activities of this compound against Trypanosoma cruzi. Ravuconazole showed very
potent in vitro anti-T… by the Kinetoplastid protozoan Trypanosoma cruzi, responsible for the …

… In this work, we describe the development and validation of improved methods to test anti-T.
cruzi compounds in vitro and in vivo using parasite lines expressing the firefly luciferase (luc…

… Cruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for
the … T. cruzi infection and is currently a clinical candidate for treatment of Chagas' disease. …

… During the in vivo analysis, we performed both the TUNEL assay, which measures the …
Our present results showed that during the in vivo infection with T. cruzi, cardiac cells undergo …

… Validation of in vivo imaging as a tool to assess efficacy of drug treatment against acute
and chronic Trypanosoma cruzi infections. (A) SCID mice infected with 10 3 bioluminescent T. …

Chagas disease (CD), a neglected tropical disease caused by Trypanosoma cruzi , remains
a serious public health problem in several Latin American countries. The available …

… y-mediated killing of the intracellular protozoan parasite Trypanosoma cruzi and on the
course of T. cruzi infection in mice were investigated. Spleen cells from mice with acute T. …

… for their activity against Trypanosoma cruzi. Our results show that … In vivo results were consistent
with those observed in vitro. … effects of these products showed the reduction of the anti-T. …

… The clonal evolution of Trypanosoma cruzi sustains scientifically the hypothesis of … This
study intended to characterize a range of biological properties of TcI, TcII and TcVI T. cruzi …

… the combined effect of benznidazole (BZ) and clomipramine (CLO) against different life-stages
of Trypanosoma cruzi in vitro and their efficacy in a murine model. Life-stages of T. …