… targets identified within key metabolic pathways. Objective: To review the state of the art of
drug targets against Trypanosoma cruzi … over the last three decades, on targets for design and …

… cruzi survival. In this work, the authors want to offer a brief overview of the different validated
targets … compiles, as much as possible, all the inhibitors reported to date against these T. …

… cruzi survivaL systems such as the gLycoLysis pathway, ceLLuLar detoxification, … targets
and their reLevant structuraL features to deveLop new drugs against American trypanosomiasis …

… Abstract: Chagas disease, caused by Trypanosoma cruzi, stands out due to its … target
organelles and molecules for the chemotherapy of Chagas disease. We consider as potential target …

Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas Disease, contains
cysteine, serine, threonine and metallo proteinases. Aspartic proteinases have not been …

… metabolism of Trypanosoma cruzi that have recently been studied as potential targets for …
-activity, and the perspectives of new compounds that inhibit these therapeutic targets. …

… decades and commonly starts when the obligate intracellular parasite Trypanosoma cruzi
gains access to cells in the skin or in the mucosa after release from reduviid insect excreta. T. …

… mechanisms underlying Trypanosoma cruzi infection, comprising specific parasite and
host elements, acquires utmost relevance for the identification of novel targets. Particularly, T. …

Chagas disease is caused by the kinetoplastid parasite Trypanosoma cruzi, which is mainly …
This review covers the cellular and molecular mechanisms involved in T. cruzi adhesion to, …

… Abstract: Chagas disease is a zoonosis caused by the parasite Trypanosoma cruzi, a haematic
… Trypanosoma cruzi has a metabolism largely based on the consumption of amino acids, …