… epigenetically repress TSC2 transcription via recruiting EZH2 to TSC2 promoter regions to
… thereby induce mTOR activation and subsequent autophagy inhibition. Autophagy can be …

… of autophagy inhibitor 3MA, ATG6 or TSC2 siRNA. Consistent with the involvement of the
Akt–TSC1/2–mTOR pathway, the phosphorylation levels of mTOR, mTOR’… , autophagy inhibitor …

… Autophagy inhibition has been shown to suppress the growth of tumor cells (6). We previously
found that constitutive activation of mTORC1 in TSC2-null … by autophagy inhibition leads to …

… TSC2-null and LAM cells maintains inhibition of the mTORC1/… of autophagy, while at the
same time restores inhibition of Akt, … Importantly, upregulation of apoptosis is selective to TSC2-…

… conversely, the inhibition of mTORc1 by raptor knockdown … mTORC1 could thus limit
autophagy in TSC2-/- cells. Here we first compared the basal autophagy level in TSC2+/+ and TSC2…

… through autophagy, we used the autophagy inhibitor 3MA or siRNA against the key … PAMAM
G3 induces autophagy via mTOR, we performed LC3 aggregation studies in TSC2 siRNA-…

… which decreases mTORC1 activity, both indirectly via TSC2 and directly via … mTORC1
activity; decrease in amino acids affects MAP4K3 and Rag GTPases, acting upstream of mTORC1…

… with Butein failed to activate autophagy and abrogated the suppression of IL-… autophagy in
OA chondrocytes via AMPK/TSC2/ULK1/mTOR pathway. Additionally, activation of autophagy …

… TSC2 becomes activated, resulting in mTORC1 repression. Since mTOR suppresses autophagy,
we … for chemo/radio-sensitization; however, the impact on autophagy of these inhibitors …

… mTORC1 signaling via TSC2 while the other drugs inhibit … that stimulate autophagy and
inhibit mTORC1 signaling, we … TSC2 +/+ and TSC2 −/− MEFs were exposed to varying …