Objective: To investigate the contribution of polymorphic variation in genes involved in the
folate-dependent homocysteine pathway in the aetiology of neural tube defects (NTD). …

… When there was low maternal folate intake, risk of NTDs was significantly increased for …
interaction effects was low for this birth defects association study, the gene–folate interactions …

… folate-replete and folate-deficient conditions; and if administration of complement activators
or selective C5a agonists can rescue defective … complement and folate interact to ensure …

… Although this second MTHFR mutation does not appear to affect plasma levels of
homocysteine or folate when it occurs in isolation, there is evidence for an interaction between the …

Diet, particularly vitamin deficiency, is associated with the risk of birth defects. The aim of
this review paper is to show the characteristics of common and severe neural-tube defects …

… Thus, we observe a gene–environment interaction such that folate deficiency induces
exencephaly … of which would have completed cranial neurulation under folate-replete conditions. …

… Low folate status interacts with impairments in one-carbon metabolism (folate utilization) to
create risk for neural tube defects. Both folate status and folate utilization are compromised by …

… Interaction of VPA with folate metabolism has long been suspected of underlying VPA’s
teratogenicity and this hypothesis is among the best characterized to date. It has been …

… Folate metabolism pathway genes have been examined for association with … tube defects
(NTDs) because folic acid supplementation reduces the risk of this debilitating birth defect. …

… tube defects (NTD) are likely to result from an interaction of several genes and environmental
factors. Because periconceptional folate … polymorphisms of the folate and homocysteine …