… role of the TFAP2A gene in the aetiology of human neural tube defects. However, our results
… study shows that CSK and MLP are not major risk factors for neural tube defects in humans. …

… Neural tube defects (NTDs) are common and severe birth defects. They arise between the
third and fourth week of embryogenesis because of partial or complete failure of neural tube …

… the presence of LoF variants in five genes, have reported … NTD genes, suggesting the
involvement of those variants in the … two independent protein truncating variants in SHROOM3 in …

… investigations of this variant and neural tube defect risk.… variant may depend on other factors
– for example, genetic, nutritional, environmental – within the population, or that this variant …

… nucleotide polymorphisms (SNPs) and location in the gene (Figure 2). All but two genetic
variants were genotyped by commercially available TaqMan allelic discrimination assays (…

… In addition, we also identified 2 candidate variants in three genes in 224 controls. There is a
… genes including CASP9, APAF1, and CASP3 contribute to etiology of neural tube defects in …

… SCRIB variants combined with variants among other PCP genes … effect of these variants on
protein function or on neural tube … Our findings imply that genetic variation might interact in a …

… Coding variants within genes that impair folate transport and accumulation may not be …
deleterious genetic variation. Nonetheless, genetic variation within the folate receptor genes does …

… ) G158A are associated with a risk of neural tube defects (NTDs) in offspring. This study
examined … Possible interactions between genetic variants of MTHFR and COMT were examined. …

… exploring the relationship between folate nutriture, genetic variation, and NTDs, we are still
… in folate metabolism affect neural tube closure. Data from genetic studies and studies of …