… several insights, and the … research focuses on aspects of the metabolism and physiology
of mycobacterial of relevance to tuberculosis drug resistance, persistence and drug discovery…

… biological network models in order to elucidate direct mechanistic insights into how antibiotics
perturb the biological … When we consider the history of the tuberculosis pathogen, which …

… involving Mycobacterium tuberculosis are reviewed and analyzed with regard to the insights
they … tuberculosis while suggesting avenues for the evolution of chemical tools, highlighting …

… newer approaches to identify anti-tubercular drugs and targets. The availability … drug
discovery. In this chapter, we focus on how systems-level modelling of Mtb can provide us insights …

… to confirm drug action, reveal new insights into compound activity, and discover new avenues
for inquiry. This review summarizes the application of Mycobacterium tuberculosis omics …

… The availability of 3D structural information has greatly helped in structure-based drug design
by presenting atomic-level insights into molecular interactions. Nonetheless, these provide …

… tuberculosis within the host presents a barrier to the development of new drugs. In this
review, we highlight the reasons that make TB drug discovery and development challenging as …

… Recently, the WHO released top 10 global threats to health in 2019, among them AMR to
tuberculosis drugs have accounted the huge contribution with 1.6 million deaths per year …

… drug targets of Mtb can provide extensive insights into the … considered the research hotspots
of anti-TB drug development in … host cells has become a focus of research in this field. In the …

… In this review, we discuss the recent successes in TB drug development and attempt to highlight
… An emerging approach to target-based drug discovery is the use of strains depleted for …