[HTML][HTML] There's plenty of room right here: Biological systems as evolved, overloaded, multi-scale machines
… The rate of evolution would be much slower without this multi-scale competency architecture—the
ability of the parts to get their job accomplished even if circumstances change [159] In …
ability of the parts to get their job accomplished even if circumstances change [159] In …
From multiscale biophysics to digital twins of tissues and organs: future opportunities for in-silico pharmacology
MT Barros, M Paci, A Tervonen… - … , and Multi-Scale …, 2024 - ieeexplore.ieee.org
… are termed multiscale … pipeline, also including some mathematical details. This article
has been accepted for publication in IEEE Transactions on Molecular, Biological, and Multi-Scale …
has been accepted for publication in IEEE Transactions on Molecular, Biological, and Multi-Scale …
The anti-tuberculosis agents under development and the challenges ahead
D Kumar, B Negi, DS Rawat - Future medicinal chemistry, 2015 - Taylor & Francis
… This review evaluates the current status of TB drug … in the anti-TB drug discovery and develop
newer drugs with new targets, … drugs available, the new drugs developed for TB and other …
newer drugs with new targets, … drugs available, the new drugs developed for TB and other …
[HTML][HTML] Prediction of host - pathogen protein interactions between Mycobacterium tuberculosis and Homo sapiens using sequence motifs
… Drug discovery for TB continues to lag behind. Co-infection with retroviruses like HIV further
complicates TB treatment. Emergence of multi-drug resistant and extensively-drug resistant …
complicates TB treatment. Emergence of multi-drug resistant and extensively-drug resistant …
[HTML][HTML] Opportunities and challenges in building a spatiotemporal multi-scale model of the human pancreatic β cell
… Here, we present a vision for creation of a spatiotemporal multi-scale model of the pancreatic
β–cell, a relevant target for understanding and modulating the pathogenesis of diabetes. …
β–cell, a relevant target for understanding and modulating the pathogenesis of diabetes. …
[PDF][PDF] Multi-scale agent-based models in immunology. A short
M Pennisi - 2021 - ceur-ws.org
… In the drug discovery pipeline, the lack of multi-scale modeling approaches able of taking …
the effects of combined immunization strategies against tuberculosis [17], and also specialized …
the effects of combined immunization strategies against tuberculosis [17], and also specialized …
[PDF][PDF] CSIRO at the ImageCLEFmed 2022 Tuberculosis Caverns Detection Challenge: A 2D and 3D deep learning detection network approach
… , which is used to extract multi-scale 3D image features, while … with a hierarchy of multi-scale
computation units with a … the conventional post-processing pipeline has been implemented ( …
computation units with a … the conventional post-processing pipeline has been implemented ( …
Entering the era of computationally driven drug development
… several steps in the drug discovery and development pipeline. The model development, …
of the multi-scale model using isoniazid, an anti-tuberculosis drug that is associated with drug-…
of the multi-scale model using isoniazid, an anti-tuberculosis drug that is associated with drug-…
Multi-scale modeling of drug action in the nervous system
H Geerts, P Roberts, A Spiros, R Carr - Systems Pharmacology and …, 2016 - Springer
… This chapter illustrates a multi-scale drug action model for CNS diseases. We show
various applications of this platform in actual CNS research and development projects. …
various applications of this platform in actual CNS research and development projects. …
Moving from point‐based analysis to systems‐based modeling: integration of knowledge to address antimicrobial resistance against MDR bacteria
… treatment evaluated using pharmacokinetic/pharmacodynamic, immunodynamics, and
multi-omics analysis to understand the multi-scale … , robust pipeline of antimicrobial agents. Here, …
multi-omics analysis to understand the multi-scale … , robust pipeline of antimicrobial agents. Here, …