Development of new tuberculosis drugs: translation to regimen composition for drug-sensitive and multidrug-resistant tuberculosis
… of drug regimens and quantifying exposure-response relationships (14, 15). Comprehensive
data sets exist for drugs used as monotherapy and in combination with others (27–33). …
data sets exist for drugs used as monotherapy and in combination with others (27–33). …
[HTML][HTML] Association between regimen composition and treatment response in patients with multidrug-resistant tuberculosis: a prospective cohort study
CM Yuen, EV Kurbatova, T Tupasi, JC Caoili… - PLoS …, 2015 - journals.plos.org
… drugs was present in the regimen (aHR 1.39, 95% CI 1.09–1.76, per drug when three effective
drugs present in regimen… , not a randomized trial, and drug regimens varied across sites. …
drugs present in regimen… , not a randomized trial, and drug regimens varied across sites. …
Principles for constructing a tuberculosis treatment regimen: the role and definition of core and companion drugs
A Van Deun, T Decroo, A Piubello… - … of Tuberculosis and …, 2018 - ingentaconnect.com
… drugs to inform the composition of treatment regimens for MDR-TB. We propose to reserve
the term ‘core drug’ for the one drug in a regimen … -line anti-tuberculosis drugs to the extent …
the term ‘core drug’ for the one drug in a regimen … -line anti-tuberculosis drugs to the extent …
Drugs in development for tuberculosis
AM Ginsberg - Drugs, 2010 - Springer
… Therefore, the primary goal of R&D efforts is to develop a three-drug regimen (although,
arguably, a two-drug combination could suffice if the treatment duration were short enough to …
arguably, a two-drug combination could suffice if the treatment duration were short enough to …
[HTML][HTML] Time to culture conversion and regimen composition in multidrug-resistant tuberculosis treatment
DB Tierney, MF Franke, MC Becerra, FA Alcántara Virú… - PloS one, 2014 - journals.plos.org
… treatment regimen composition on culture conversion. Well-designed clinical trials of new
anti-tuberculosis drugs require this information to establish optimized background regimens for …
anti-tuberculosis drugs require this information to establish optimized background regimens for …
[HTML][HTML] Short-course regimen for multidrug-resistant tuberculosis: a decade of evidence
A Trébucq, T Decroo, A Van Deun, A Piubello… - Journal of clinical …, 2019 - mdpi.com
… MDR-TB regimens, describe their different compositions, their results in national tuberculosis
… With over 80% success, the regimen performs much better than longer regimens (usually …
… With over 80% success, the regimen performs much better than longer regimens (usually …
[HTML][HTML] Evaluation of a standardized treatment regimen of anti-tuberculosis drugs for patients with multi-drug-resistant tuberculosis (STREAM): study protocol for a …
AJ Nunn, ID Rusen, A Van Deun, G Torrea… - Trials, 2014 - Springer
… WHO recommendations are guidelines which include some latitude in their implementation,
resulting in different regimen compositions in different settings. Mandating any one …
resulting in different regimen compositions in different settings. Mandating any one …
[HTML][HTML] Tuberculosis chemotherapy: current drug delivery approaches
LC Du Toit, V Pillay, MP Danckwerts - Respiratory research, 2006 - Springer
… of the principal anti-tuberculosis drugs, which attains segregated … by the need of multi-drug
regimens that need to be … RIF-INH multiparticulate composition intended for facilitated oral …
regimens that need to be … RIF-INH multiparticulate composition intended for facilitated oral …
[HTML][HTML] Treating tuberculosis with high doses of anti-TB drugs: mechanisms and outcomes
Y Xu, J Wu, S Liao, Z Sun - Annals of clinical microbiology and …, 2017 - Springer
… of high dose of anti-tuberculosis drugs. This review will help … of high dose anti-TB drug
regimens, the exact mechanisms … It has been found that body composition, regional blood flow …
regimens, the exact mechanisms … It has been found that body composition, regional blood flow …
[HTML][HTML] Comparison of the safety and efficacy of a fixed-dose combination regimen and separate formulations for pulmonary tuberculosis treatment
… However, the composition and dosage recommendations for … -tuberculosis regimens for
pulmonary tuberculosis treatment. … Tuberculosis drug issues: prices, fixed-dose combinatsion …
pulmonary tuberculosis treatment. … Tuberculosis drug issues: prices, fixed-dose combinatsion …
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