Emerging therapeutics, technologies, and drug development strategies to address patient nonadherence and improve tuberculosis treatment

M Garcia-Cremades, BP Solans… - Annual review of …, 2022 - annualreviews.org
… This study determined that existing TB regimens were far less … Patient phenotypes can impact
response to tuberculosis drugs, … tuberculosis drugs: translation to regimen composition for …

Aggressive regimens for multidrug-resistant tuberculosis reduce recurrence

MF Franke, SC Appleton, CD Mitnick… - Clinical Infectious …, 2013 - academic.oup.com
… Patients were excluded from analyses if we lacked data on their regimen composition or
if … to ensure adequate diabetes and MDR tuberculosis drug delivery, and followed closely …

Mycobactericidal effects of different regimens measured by molecular bacterial load assay among people treated for multidrug-resistant tuberculosis in Tanzania

PM Mbelele, EA Mpolya, E Sauli, B Mtafya… - Journal of clinical …, 2021 - Am Soc Microbiol
… , despite the drug class’ … tuberculosis killing rates measured by tuberculosis molecular
bacterial load assay (TB-MBLA) in sputa correlate with composition of the RR/MDR-TB regimen. …

Drivers and trajectories of resistance to new first-line drug regimens for tuberculosis

S Shrestha, GM Knight, M Fofana… - Open forum …, 2014 - academic.oup.com
… expression for the effective reproductive ratio, which delineates how different drivers feature
in its composition: … Global tuberculosis drug development pipeline: the need and the reality …

New tuberculosis drugs in development

BE Laughon - Current Topics in Medicinal Chemistry, 2007 - ingentaconnect.com
… Available drugs to treat opportunistic infections (including tuberculosis) do not exhibit …
and prophylaxis regimens against recurrence of infections. Existing anti-tuberculosis drugs

[PDF][PDF] Operational guide for national tuberculosis control programmes on the introduction and use of fixed-dose combination drugs

S Phanouvong, H Vrakking, L Blanc… - 2002 - apps.who.int
… -drug regimens for treatment of primary TB with fixed-dose combinations. Use of WHOrecommended
3- and 4-drug … with selecting drug regimens and calculating drug needs prior to …

Simultaneous determination of first‐line anti‐tuberculosis drugs and their major metabolic ratios by liquid chromatography/tandem mass spectrometry

SH Song, SH Jun, KU Park, Y Yoon… - … Journal Devoted to …, 2007 - Wiley Online Library
… The treatment of tuberculosis is comprised of combinatorial regimens of three or four … Even
though during test development we changed mobile phase compositions and decreased the …

[HTML][HTML] Applicability of the shorter 'Bangladesh regimen'in high multidrug-resistant tuberculosis settings

G Sotgiu, S Tiberi, R Centis, L D'Ambrosio… - International Journal of …, 2017 - Elsevier
… The rational composition of this new regimen is similar to that of … drugs and the inclusion
of a fluoroquinolone, a second-line injectable drug, and two other ‘companion’ drugs (eg, drugs

[HTML][HTML] Programmatic management of rifampicin-resistant tuberculosis with standard regimen in Cameroon: a retrospective cohort study

CG Jouego, T Gils, A Piubello, V Mbassa… - International Journal of …, 2022 - Elsevier
… to overall death in this study population and shows the importance of SL DST availability
during Rr-TB treatment in order to guide clinical decision and consequent regimen composition. …

Multidrug-resistant tuberculosis treatment outcomes in Karakalpakstan, Uzbekistan: treatment complexity and XDR-TB among treatment failures

HS Cox, S Kalon, S Allamuratova, V Sizaire, ZN Tigay… - PloS one, 2007 - journals.plos.org
… %) requiring the composition of their treatment regimens to be changed at least once during
the treatment course (Table 2). The most common drugs added to treatment regimens after …