… that host immunity plays an important role in the host-pathogen interaction occurring in
persons exposed to M. tuberculosis. Understanding the components of this host response at a …

… tuberculosis (Mtb) strains and a rise in the reservoir of latent infection. Host immune status
… and prompts the host to elicit an immune response that favours its persistence. Adjunctive …

… As a strategy to escape host immunity, intracellular Mtb selectively modulates autophagy to
… host immune cells [84,85], it is relevant to develop host-directed therapy against tuberculosis, …

… Here we present the first computational platform for the study of antibiotic treatment of TB
that integrates host immunity, PK (in plasma and lung tissue) and PD with spatial resolution. …

… Host immune factors controlling M. tuberculosis infection are discussed in more detail later
in this review; we emphasize here the similarities in host-protective factors in both mouse …

… Individuals with LTBI have 5–10% lifetime risk of developing active TB and host immune …
host innate and adaptive immune response in the control of Mtb infection (6). The host immunity …

… We argue that the immunology of mouse tuberculosis is similar in important ways to that in
… mouse tuberculosis and tuberculosis in the guinea pig and rabbit are models of tuberculosis …

… are not sufficient to predict tuberculosis treatment outcome and do not measure … Host-derived
biomarkers that predict tuberculosis treatment outcome could greatly enhance tuberculosis …

… .tb while concentrating the immune response to a limited area. … for dictating both the host
immune and bacterial response. … and play a crucial role in immunity and disease. Here we …

… with regards to whether they measured microbial or host characteristics. However, by directly
modulating the host immune response, tuberculosis HDT agents can alter the relationship …