Detection of solid tumor molecular residual disease (MRD) using circulating tumor DNA (ctDNA)

RI Chin, K Chen, A Usmani, C Chua, PK Harris… - Molecular diagnosis & …, 2019 - Springer
… Circulating tumor DNA (ctDNA) is a component of cell-free DNA that is shed by malignant
tumors into the bloodstream and other bodily fluids. Levels of ctDNA are typically low, …

The promise of circulating tumor DNA (ctDNA) in the management of early-stage colon cancer: a critical review

S Chakrabarti, H Xie, R Urrutia, A Mahipal - Cancers, 2020 - mdpi.com
tumor DNA (ctDNA), a fraction of cell-free DNA (cfDNA) in the bloodstream that originates from
the neoplastic cells and carry tumor… Several recent studies suggest that ctDNA-guided risk …

Circulating tumor DNA (ctDNA) in the era of personalized cancer therapy

F Khatami, SM Tavangar - Journal of Diabetes & Metabolic Disorders, 2018 - Springer
ctDNA can be a potential source of tumor DNA alteration pursuing for the documentation of
tumor… A panel of individualized junctions consequent from tumor DNA possibly will be an …

Utility of genomic assessment of blood-derived circulating tumor DNA (ctDNA) in patients with advanced lung adenocarcinoma

MC Schwaederlé, SP Patel, H Husain, M Ikeda… - Clinical Cancer …, 2017 - AACR
… Other reasons for these differences could include, but not be limited to, factors related to
tumor heterogeneity and the propensity of tumor DNA to shed into the blood, as well as the fact …

[HTML][HTML] A dual biomarker detection platform for quantitating circulating tumor DNA (ctDNA)

C Cai, Z Guo, Y Cao, W Zhang, Y Chen - Nanotheranostics, 2018 - ncbi.nlm.nih.gov
… can detect the concentration of circulating tumor DNA (ctDNA), which is significantly higher …
the clinical potential of ctDNA, but also the challenges involved in analysis of it. Tumor DNA is …

[HTML][HTML] Non-invasive diagnosis of early-stage lung cancer using high-throughput targeted DNA methylation sequencing of circulating tumor DNA (ctDNA)

W Liang, Y Zhao, W Huang, Y Gao, W Xu, J Tao… - Theranostics, 2019 - ncbi.nlm.nih.gov
DNA methylation profiling by high throughput DNAtumors from benign lesions. Then
we filtered out methylation patterns exhibiting high background in circulating tumor DNA (ctDNA) …

Undetectable circulating tumor DNA (ctDNA) levels correlate with favorable outcome in metastatic melanoma patients treated with anti-PD1 therapy

T Seremet, Y Jansen, S Planken, H Njimi… - Journal of translational …, 2019 - Springer
… Applications for quantitative measurement of BRAF V600 mutant cell-free tumor DNA in
the plasma of patients with metastatic melanoma. Melanoma Res. 2016;26:157–63. …

Advances in circulating tumor DNA analysis

S Perakis, M Auer, J Belic, E Heitzer - Advances in clinical chemistry, 2017 - Elsevier
ctDNA and associated landmark developments. Second, we present the current knowledge
of the biology of DNA… the clinical utility of ctDNA analysis for the most common tumor entities. …

Circulating tumor DNA (ctDNA) as a pan-cancer screening test: is it finally on the horizon?

MJ Duffy, EP Diamandis, J Crown - Clinical Chemistry and …, 2021 - degruyter.com
… Like proteins, tumor DNA also can be released into the circulation. Such circulating tumor
DNA (ctDNA) can be differentiated from normal cell DNA by the presence of specific genetic …

Detection of circulating tumor DNA in early-and late-stage human malignancies

C Bettegowda, M Sausen, RJ Leary, I Kinde… - Science translational …, 2014 - science.org
… We purified plasma and tumor DNA using regimented protocols for all samples and used
digital technologies to evaluate ctDNA levels from each tumor so that we could report the …