Early assessment of lung cancer immunotherapy response via circulating tumor DNA

SB Goldberg, A Narayan, AJ Kole, RH Decker… - Clinical Cancer …, 2018 - AACR
… challenging to interpret because tumors often shrink slowly … tumor cell death in real time
by quantifying changes in circulating tumor DNA (ctDNA) levels could enable early assessment

Circulating tumor DNA as an early cancer detection tool

A Campos-Carrillo, JN Weitzel, P Sahoo… - Pharmacology & …, 2020 - Elsevier
Circulating tumor DNA holds substantial promise as an early detection biomarker, particularly
for cancers that do not have currently accepted screening methodologies, such as ovarian, …

Circulating-tumor DNA as an early detection and diagnostic tool

TM Butler, PT Spellman, J Gray - Current opinion in genetics & …, 2017 - Elsevier
tumor change over time. One approach to identifying the spatial and temporal complexity of
tumors is the analysis of tumor DNA … multiple mutations to assess whether specific mutations, …

Circulating tumor DNA: clinical monitoring and early detection

RB Corcoran - Annual Review of Cancer Biology, 2019 - annualreviews.org
… The ability to assess the presence, level, and composition of tumor DNA from a routine,
noninvasive blood draw has opened the door to a broad array of high-impact clinical applications…

Early assessment of circulating tumor DNA after curative‐intent resection predicts tumor recurrence in early‐stage and locally advanced non‐small‐cell lung cancer

S Waldeck, J Mitschke, S Wiesemann… - Molecular …, 2022 - Wiley Online Library
tumor DNA (ctDNA) has demonstrated great potential as a noninvasive biomarker to assess
minimal residual disease (MRD) and profile tumor … during and after tumor resection, or its …

Early assessment of molecular progression and response by whole-genome circulating tumor DNA in advanced solid tumors

AA Davis, WT Iams, D Chan, MS Oh, RW Lentz… - Molecular cancer …, 2020 - AACR
… Treatment response assessment for patients with advanced solid tumors is complex and …
circulating tumor DNA (ctDNA) were used to assess response or resistance to treatment early in …

Monitoring daily dynamics of early tumor response to targeted therapy by detecting circulating tumor DNA in urine

H Husain, VO Melnikova, K Kosco, B Woodward… - Clinical cancer …, 2017 - AACR
… Purpose: Noninvasive drug biomarkers for the early assessment of tumor response can enable
… Circulating tumor DNA (ctDNA) is released into the circulation by tumor cell turnover and …

[HTML][HTML] Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer

J Tie, I Kinde, Y Wang, HL Wong, J Roebert… - Annals of …, 2015 - Elsevier
… For each patient, one tumor mutation was selected to assess the presence and the level
of ctDNA in plasma samples using a digital genomic assay termed Safe-SeqS. …

[HTML][HTML] Circulating tumor DNA allele fraction: a candidate biological signal for multicancer early detection tests to assess the clinical significance of cancers

J Bredno, O Venn, X Chen, P Freese… - The American Journal of …, 2022 - Elsevier
… circulating tumor allele fraction (cTAF)], which could inform prognosis and help assess the
cancer's clinical significance. This review discusses the factors affecting circulating tumor DNA

Role of circulating tumor DNA in the management of early‐stage lung cancer

H Zhao, KZ Chen, BG Hui, K Zhang, F Yang… - Thoracic …, 2018 - Wiley Online Library
… Circulating tumor DNA (ctDNA) is free DNA shed from tumor … High concordance between
ctDNA and tumor DNA plays a … be applied in early diagnosis and can be used to assess the …