… In the next paragraphs, we review the main evidences pointing at a functional link between
lactate production and angiogenesis in the context of wound healing, which would logically …

… In summary, accumulation of lactate in solid tumors is a … for energy production and seems
to contribute to elevated lactate … to stimulate IL-8–dependent angiogenesis and tumor growth. …

… that inhibiting lactate production and blocking lactate sources … Lactic acid is involved in TME,
tumor growth and metastasis, … of lactic acid in tumor tissue are connected to tumor growth, …

… Lastly, we explore the efforts to target the lactate production and its transport … lactate
production. HIF1-α has been implicated in breast cancer tumor growth and metastasis, and in tumor …

… tumoral lactate production. Overall, the contribution of lactate produced by immune cells to
the tumor … Lactic acid also favors tumor growth by polarizing macrophages to an M2-like state, …

… tumor microenvironment induced by lactate is also presented. Finally, we discuss the possible
targeting of lactate production … tumor, promoting immunosuppression and tumor growth (…

… stromal-epithelial lactate shuttle in human tumors, analogous to the lactate shuttles that …
lactate or ketones in human tumor xenograft models was sufficient to increase both tumor growth …

… These metabolic changes could advantageously limit tumor growth, while disadvantageously
impairing tumor immune … Is the lactate that accumulates into the tumor locally produced? …

… First, high lactic acid production might benefit tumor cells by allowing them to withstand …
acid concentrations might create an immune environment beneficial to tumor growth. Both …

… To evaluate if Cdc42 expression in stromal cells is able to promote tumor growth in vivo,
we used a human tumor xenograft model. Control, SMA or Cdc42 fibroblasts were coinjected …