… highly expressed on T cells in the tumor microenvironment (TME) due to persistent activation
… the whole suppressive microenvironment. In this review, we postulate that tumor cells are …

… of tumor cells to modify their metabolism and release several metabolites to impair the function
of immune cells… involved in the TME that affect the anti-tumor immune function of NK cells. …

… tumor microenvironment. In the immunosuppressive TME, malignant cells debilitate the
antitumor immune … collaboration with cancer-associated stromal cells, and exploit immune scape …

… partitioning in HFD tumors, impairing CD8 + T cell infiltration and function. Blocking metabolic
reprogramming by tumor cells in obese mice improves anti-tumor immunity. Analysis of …

… tumor microenvironment for effective immune responses. We report that IFN-γ plays a role in
T cell trafficking to the tumor microenvironment … molecule VCAM-1 on tumor vasculature and …

… immune cells. We also consider the role of an acidic TME in suppressing anticancer immunity.
… insights to help translate this new knowledge into impactful anticancer immune therapies. …

… Cancer cells are metabolically vigorous and are superior in the uptake of nutrients and in the
release of the tumor microenvironment (… it difficult for the cytotoxic immune cells to adapt to …

… help direct and improve the actions of various cancer therapies, notably immunotherapies
that work by potentiating host antitumor immune responses. Here, we review the composition …

… These tumor-targeted therapies have the potential to induce systemic immunity without the
… these affect systemic antitumor immunity such that disseminated tumor cells are eliminated, …

… p53 in the tumor microenvironment (TME) also … antitumor immunity. Using a pharmacological
p53 activator nutlin-3a, we show that local p53 activation in TME comprising overt tumor-…