The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets

SL Wood, M Pernemalm, PA Crosbie… - Cancer treatment …, 2014 - Elsevier
Lung cancer originates within a microenvironment characterized by high degrees of
vascularization and oxygenation. Uniquely lungs … risk factor for lung cancer development. …

The tumor microenvironment in non–small-cell lung cancer

EE Graves, A Maity, QT Le - Seminars in radiation oncology, 2010 - Elsevier
… both in vitro and in vivo, and it improves tumor oxygenation in A549 lung carcinoma xenografts.
Nelfinavir can also increase blood flow in tumors (Cerniglia and Maity, unpublished data, …

Therapeutic implications of tumor microenvironment in lung cancer: focus on immune checkpoint blockade

C Genova, C Dellepiane, P Carrega… - Frontiers in …, 2022 - frontiersin.org
Tumor microenvironment (TME) might influence response to immunotherapy due to its …
lung cancer from the perspective of TME pointed out a complex scenario where tumor

Tumor microenvironment characterization identifies two lung adenocarcinoma subtypes with specific immune and metabolic state

J Huang, J Li, S Zheng, Z Lu, Y Che, S Mao… - Cancer …, 2020 - Wiley Online Library
… 3.1 Landscape of TME cells in lung adenocarcinoma To analyze the landscape of tumor
stromal cells in lung adenocarcinoma, we collected a TCGA-LUAD dataset and a meta-GEO …

A risk model developed based on tumor microenvironment predicts overall survival and associates with tumor immunity of patients with lung adenocarcinoma

J Wu, L Li, H Zhang, Y Zhao, H Zhang, S Wu, B Xu - Oncogene, 2021 - nature.com
Tumor microenvironment (TME) has been reported to exhibit a crucial effect in lung cancer.
… overall survival (OS) of patients with lung adenocarcinoma (LUAD) based on these genes. …

Computational staining of pathology images to study the tumor microenvironment in lung cancer

S Wang, R Rong, DM Yang, J Fujimoto, S Yan, L Cai… - Cancer research, 2020 - AACR
… Although this tool was developed in lung adenocarcinoma pathology images, our results …
and neck cancer, breast cancer, and lung cancer squamous cell carcinoma pathology image …

[HTML][HTML] Immune profile of the tumor microenvironment and the identification of a four-gene signature for lung adenocarcinoma

T Fan, M Zhu, L Wang, Y Liu, H Tian, Y Zheng… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
tumor microenvironment are key factors affecting the progression of lung adenocarcinomas
(… Using the cancer gene expression dataset from The Cancer Genome Atlas (TCGA) program…

… transition is associated with a distinct tumor microenvironment including elevation of inflammatory signals and multiple immune checkpoints in lung adenocarcinoma

Y Lou, L Diao, ERP Cuentas, WL Denning, L Chen… - Clinical Cancer …, 2016 - AACR
lung adenocarcinomas displaying a “mesenchymal” phenotype are associated with distinct
tumor microenvironment … preexisting immunity and increases in tumor infiltration by CD3 + T …

Analysis of prognostic genes in the tumor microenvironment of lung adenocarcinoma

Z Xu, M Zhao, W Chen, K Li, F Qin, W Xiang, Y Sun… - PeerJ, 2020 - peerj.com
… processes and the response of cancer to immunotherapy. Thus, … lung adenocarcinomas
(LUAD) using the ESTIMATE algorithm, which also significantly affects the prognosis of cancer. …

Identification of key genes in the tumor microenvironment of lung adenocarcinoma

W Long, Q Li, J Zhang, H Xie - Medical Oncology, 2021 - Springer
… The tumor microenvironment plays an important role in tumor … with the microenvironment of
lung adenocarcinoma (LUAD). … cells in malignant tumors were downloaded from The Cancer